ChEMBL ligand: CHEMBL3623290 (Azd 3759, Azd-3759, Azd3759, AZD3759, Zorifertinib)
D2 receptor/Dopamine D2 receptor in Human [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] There should be some charts here, you may need to enable JavaScript!
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968] There should be some charts here, you may need to enable JavaScript!
Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416]
ChEMBL	Inhibition of recombinant D2 receptor (unknown origin)	B	6.1	pIC50	797	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533]
ChEMBL	Inhibition of EGFR (unknown origin) by HTRF assay in presence of 2 mM of ATP	B	6.99	pIC50	102	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
ChEMBL	Inhibition of EGFR phosphorylation in human H838 cells	B	7.19	pIC50	64.5	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
ChEMBL	Inhibition of EGFR L858R mutant (unknown origin) by HTRF assay in presence of 2 mM of ATP	B	8.12	pIC50	7.6	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
GtoPdb	Inhibition of EGFRL858R in vitro.	-	8.14	pIC50	7.2	nM	IC50	J Med Chem (2015) 58: 8200-15 [PMID:26313252]
ChEMBL	Inhibition of EGFR L858R mutant phosphorylation in human H3255 cells	B	8.14	pIC50	7.2	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
ChEMBL	Inhibition of human EGFR using poly[Glu:Tyr] (4:1) as substrate measured after 20 mins in presence of [gamma33P]ATP by filter-binding assay	B	9.3	pIC50	<0.5	nM	IC50	ACS Med Chem Lett (2019) 10: 22-26 [PMID:30655941]
GtoPdb	Inhibition of wild type EGFR in vitro, at Km of ATP.	-	9.52	pIC50	0.3	nM	IC50	J Med Chem (2015) 58: 8200-15 [PMID:26313252]
ChEMBL	Inhibition of EGFR (unknown origin) by HTRF assay in presence of Km of ATP	B	9.52	pIC50	0.3	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
ChEMBL	Inhibition of EGFR L858R mutant (unknown origin) by HTRF assay in presence of Km of ATP	B	9.7	pIC50	0.2	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of recombinant Src (unknown origin) after 40 mins by scintillation counting analysis in presence of [gamma33P]-ATP	B	6.21	pIC50	622	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
kinase insert domain receptor/Vascular endothelial growth factor receptor 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL279] [GtoPdb: 1813] [UniProtKB: P35968]
ChEMBL	Inhibition of recombinant KDR (unknown origin) after 40 mins by scintillation counting analysis in presence of [gamma33P]-ATP	B	6.81	pIC50	156	nM	IC50	J Med Chem (2015) 58: 8200-8215 [PMID:26313252]
Kv11.1 in Human [GtoPdb: 572] [UniProtKB: Q12809]
GtoPdb	Channel inhibition measured in a conventional manual whole-cell patch clamp study.	-	4.88	pIC50	13300	nM	IC50	J Med Chem (2015) 58: 8200-15 [PMID:26313252]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]