peptide 18 [PMID: 24350995] [Ligand Id: 8658] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3115771 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| furin, paired basic amino acid cleaving enzyme/Furin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958] | ||||||||
| ChEMBL | Inhibition of human recombinant furin expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 2/Prohormone convertase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2433] [GtoPdb: 2383] [UniProtKB: P16519] | ||||||||
| ChEMBL | Inhibition of human PC2 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 6/Subtilisin/kexin type 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2951] [GtoPdb: 2386] [UniProtKB: P29122] | ||||||||
| ChEMBL | Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 8.51 | pKi | 3.1 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 8.51 | pKi | 3.1 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] | ||||||||
| GtoPdb | - | - | 7.86 | pKi | 13.8 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| ChEMBL | Inhibition of human PC7 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 7.86 | pKi | 13.8 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
