peptide 18 [PMID: 24350995] [Ligand Id: 8658] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3115771
  • furin, paired basic amino acid cleaving enzyme/Furin in Human [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958]
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  • proprotein convertase subtilisin/kexin type 2/Prohormone convertase 2 in Human [ChEMBL: CHEMBL2433] [GtoPdb: 2383] [UniProtKB: P16519]
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  • proprotein convertase subtilisin/kexin type 6/Subtilisin/kexin type 6 in Human [ChEMBL: CHEMBL2951] [GtoPdb: 2386] [UniProtKB: P29122]
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  • proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
furin, paired basic amino acid cleaving enzyme/Furin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958]
ChEMBL Inhibition of human recombinant furin expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr B 8.37 pKi 4.3 nM Ki J. Med. Chem. (2014) 57: 98-109 [PMID:24350995]
GtoPdb - - 8.37 pKi 4.3 nM Ki J Med Chem (2014) 57: 98-109 [PMID:24350995]
proprotein convertase subtilisin/kexin type 2/Prohormone convertase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2433] [GtoPdb: 2383] [UniProtKB: P16519]
ChEMBL Inhibition of human PC2 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr B 9.62 pKi 0.24 nM Ki J. Med. Chem. (2014) 57: 98-109 [PMID:24350995]
GtoPdb - - 9.62 pKi 0.24 nM Ki J Med Chem (2014) 57: 98-109 [PMID:24350995]
proprotein convertase subtilisin/kexin type 6/Subtilisin/kexin type 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2951] [GtoPdb: 2386] [UniProtKB: P29122]
ChEMBL Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr B 8.51 pKi 3.1 nM Ki J. Med. Chem. (2014) 57: 98-109 [PMID:24350995]
GtoPdb - - 8.51 pKi 3.1 nM Ki J Med Chem (2014) 57: 98-109 [PMID:24350995]
proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549]
GtoPdb - - 7.86 pKi 13.8 nM Ki J Med Chem (2014) 57: 98-109 [PMID:24350995]
ChEMBL Inhibition of human PC7 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr B 7.86 pKi 13.8 nM Ki J. Med. Chem. (2014) 57: 98-109 [PMID:24350995]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]