peptide 18 [PMID: 24350995] [Ligand Id: 8658] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3115771 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| furin, paired basic amino acid cleaving enzyme/Furin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2611] [GtoPdb: 2366] [UniProtKB: P09958] | ||||||||
| ChEMBL | Inhibition of human recombinant furin expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 8.37 | pKi | 4.3 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 2/Prohormone convertase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2433] [GtoPdb: 2383] [UniProtKB: P16519] | ||||||||
| ChEMBL | Inhibition of human PC2 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 9.62 | pKi | 0.24 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 6/Subtilisin/kexin type 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2951] [GtoPdb: 2386] [UniProtKB: P29122] | ||||||||
| ChEMBL | Inhibition of human recombinant PACE4 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 8.51 | pKi | 3.1 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| GtoPdb | - | - | 8.51 | pKi | 3.1 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| proprotein convertase subtilisin/kexin type 7/Subtilisin/kexin type 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2232] [GtoPdb: 2387] [UniProtKB: Q16549] | ||||||||
| GtoPdb | - | - | 7.86 | pKi | 13.8 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
| ChEMBL | Inhibition of human PC7 expressed in drosophila schneider 2 cells using pyroGlu-Arg-Thr-Lys-Arg-AMC as substrate after 1 hr | B | 7.86 | pKi | 13.8 | nM | Ki | J Med Chem (2014) 57: 98-109 [PMID:24350995] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
