clofazimine

Ligand id: 9184

Name: clofazimine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 41.69
Molecular weight 472.12
XLogP 8.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1986))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
N,5-bis(4-chlorophenyl)-3-propan-2-yliminophenazin-2-amine
International Nonproprietary Names
INN number INN
2248 clofazimine
Synonyms
Lamprene®
Comments
Clofazimine is a phenazine dye with anti-mycobacterial action (possibly via DNA binding) but is no longer perscribed in the US. It also has anti-inflammatory activities. State-dependent block of Kv1.3 channels by clofazimine offers therapeutic potential for selective immunosuppression in the context of autoimmune diseases in which Kv1.3-expressing T cells play a significant role [2].
Database Links
ChEMBL Ligand CHEMBL1292
GtoPdb PubChem SID 315661264
PubChem CID 2794
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