octopamine [Ligand Id: 2149] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL53929 (ND 50, ND-50, NSC-757399, Octopamina, Octopamine)
  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
There should be some charts here, you may need to enable JavaScript!
  • TA1 receptor in Human [GtoPdb: 364] [UniProtKB: Q96RJ0]
  • TA1 receptor in Mouse [GtoPdb: 364] [UniProtKB: Q923Y8]
  • TA1 receptor/Trace amine-associated receptor 1 in Rat [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay B 7.62 pEC50 24 nM EC50 Nature (2007) 450: 553-556 [PMID:18033297]
TA1 receptor in Human [GtoPdb: 364] [UniProtKB: Q96RJ0]
GtoPdb - - 5.8 pEC50 - - - Proc Natl Acad Sci USA (2001) 98: 8966-71 [PMID:11459929];
Mol Pharmacol (2008) 74: 585-594 [PMID:18524885];
J Pharmacol Exp Ther (2007) 320: 475-85 [PMID:17038507];
Biochem J (2009) 424: 39-45 [PMID:19725810];
PLoS ONE (2011) 6: e27073 [PMID:22073124]
TA1 receptor in Mouse [GtoPdb: 364] [UniProtKB: Q923Y8]
GtoPdb - - 5.8 pEC50 - - - Genes Brain Behav (2007) 6: 628-39 [PMID:17212650];
Biochem J (2009) 424: 39-45 [PMID:19725810]
TA1 receptor/Trace amine-associated receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
ChEMBL Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr F 5.89 pEC50 1300 nM EC50 J Med Chem (2017) 60: 2605-2628 [PMID:28244748]
GtoPdb - - 5.9 pEC50 - - - Mol Pharmacol (2001) 60: 1181-8 [PMID:11723224]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]