octopamine [Ligand Id: 2149] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL53929 (Octopamine, ND-50)
  • 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
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  • TA1 receptor in Human [GtoPdb: 364] [UniProtKB: Q96RJ0]
  • TA1 receptor in Mouse [GtoPdb: 364] [UniProtKB: Q923Y8]
  • TA1 receptor/Trace amine-associated receptor 1 in Rat [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098]
ChEMBL Activity at SER3 receptor expressed in HEK293 cells assessed as increase in calcium by calcium imaging assay B 7.62 pEC50 24 nM EC50 Nature (2007) 450: 553-556 [PMID:18033297]
TA1 receptor in Human [GtoPdb: 364] [UniProtKB: Q96RJ0]
GtoPdb - - 5.8 pEC50 - - - Proc. Natl. Acad. Sci. U.S.A. (2001) 98: 8966-71 [PMID:11459929];
Mol. Pharmacol. (2008) 74: 585-594 [PMID:18524885];
J. Pharmacol. Exp. Ther. (2007) 320: 475-85 [PMID:17038507];
Biochem. J. (2009) 424: 39-45 [PMID:19725810];
PLoS ONE (2011) 6: e27073 [PMID:22073124]
TA1 receptor in Mouse [GtoPdb: 364] [UniProtKB: Q923Y8]
GtoPdb - - 5.8 pEC50 - - - Genes Brain Behav. (2007) 6: 628-39 [PMID:17212650];
Biochem. J. (2009) 424: 39-45 [PMID:19725810]
TA1 receptor/Trace amine-associated receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3833] [GtoPdb: 364] [UniProtKB: Q923Y9]
ChEMBL Agonist activity at rat N-terminal FLAG-tagged TAAR1 expressed in HEK293 cells assessed as [3H]cAMP accumulation measured after 1 hr B 5.89 pEC50 1300 nM EC50 J Med Chem (2017) 60: 2605-2628 [PMID:28244748]
GtoPdb - - 5.9 pEC50 - - - Mol. Pharmacol. (2001) 60: 1181-8 [PMID:11723224]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]