paracetamol [Ligand Id: 5239] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL112 (Fennings, Calpol, Panaleve, Phenaphen, Disprol, Dafalgan, Apap, Abdine, Hedex, Rimadol, Paravict, Acephen, Tixymol, Calpol six plus fastmelts, Panadol actifast, Junior parapaed, Medinol over 6, Perfalgan, Medised plain, Tramil 500, Cupanol, Medinol, Ofirmev, Alvedon, Panadol, Medinol under 6, NSC-109028, Paracetamol, Infadrops, Datril, Disprol jnr, Injectapap, Paramin, Miradol, Panadol oa, Disprol infant, Parapaed six plus, Placidex, Mandanol, Neopap, Panadol jnr, Salzone, Panaleve 6 plus, Parapaed jnr, Panadol advan, NSC-3991, Angiers, Acetaminophen, Tylenol, Galpamol, Medinol for children, Paldesic, Panadol actifast solb, Child lemsip, Calpol six plus, Disprol paed, Infants' feverall)
  • 5-lipoxygenase activating protein in Human [ChEMBL: CHEMBL4550] [UniProtKB: P20292]
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  • Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
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  • bromodomain containing 4/Bromodomain-containing protein 4 in Human [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
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  • carbonic anhydrase 1/Carbonic anhydrase I in Human [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
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  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 4/Carbonic anhydrase IV in Human [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • carbonic anhydrase 7/Carbonic anhydrase VII in Human [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
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  • carbonic anhydrase 12/Carbonic anhydrase XII in Human [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
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  • carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
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  • carbonic anhydrase 14/Carbonic anhydrase XIV in Human [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
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  • COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
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  • COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
5-lipoxygenase activating protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4550] [UniProtKB: P20292]
ChEMBL Inhibition of FLAP B 4.36 pIC50 44000 nM IC50 J. Med. Chem. (2008) 51: 4059-4067 [PMID:18459759]
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) B 4.55 pIC50 28380 nM IC50 DrugMatrix in vitro pharmacology data
bromodomain containing 4/Bromodomain-containing protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163125] [GtoPdb: 1945] [UniProtKB: O60885]
ChEMBL Inhibition of 3F-Tyr-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli by isothermal titration calorimetry B 3.6 pKd 250000 nM Kd MedChemComm (2015) 6: 1587-1604
ChEMBL Inhibition of 5F-Trp-tagged BRD4 bromodomain-1 (unknown origin) expressed in Escherichia coli by isothermal titration calorimetry B 3.6 pKd 250000 nM Kd MedChemComm (2015) 6: 1587-1604
Carbonic anhydrase 15 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5973] [UniProtKB: Q99N23]
ChEMBL Inhibition of mouse recombinant carbonic anhydrase 15 by stopped-flow CO2 hydrase assay B 5.03 pKi 9230 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay B 5 pKi 10000 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydration assay B 5 pKi 10000 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 1 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5 pKi 10000 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay B 5.21 pKi 6200 nM Ki Bioorg. Med. Chem. Lett. (2008) 18: 3593-3596 [PMID:18501600]
ChEMBL Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydration assay B 5.21 pKi 6200 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 5.21 pKi 6200 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
Carbonic anhydrase III in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2885] [UniProtKB: P07451]
ChEMBL Inhibition of human carbonic anhydrase 3 by stopped-flow CO2 hydration assay B 5.15 pKi 7100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748]
ChEMBL Inhibition of human carbonic anhydrase 4 by stopped-flow CO2 hydration assay B 4.94 pKi 11400 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Inhibition of human carbonic anhydrase 9 catalytic domain by stopped-flow CO2 hydration assay B 4.15 pKi 70700 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
ChEMBL Inhibition of human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assay B 4.15 pKi 70700 nM Ki Bioorg. Med. Chem. Lett. (2015) 25: 5636-5641 [PMID:26520662]
carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166]
ChEMBL Inhibition of human carbonic anhydrase 7 by stopped-flow CO2 hydration assay B 5.04 pKi 9100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570]
ChEMBL Inhibition of human carbonic anhydrase 12 catalytic domain by stopped-flow CO2 hydration assay B 5.39 pKi 4100 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 13/Carbonic anhydrase XIII in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2186] [GtoPdb: 2748] [UniProtKB: Q9D6N1]
ChEMBL Inhibition of mouse carbonic anhydrase 13 by stopped-flow CO2 hydration assay B 4.52 pKi 30300 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
carbonic anhydrase 14/Carbonic anhydrase XIV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3510] [GtoPdb: 2598] [UniProtKB: Q9ULX7]
ChEMBL Inhibition of human carbonic anhydrase 14 by stopped-flow CO2 hydration assay B 4.97 pKi 10600 nM Ki Bioorg. Med. Chem. (2008) 16: 7424-7428 [PMID:18579385]
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177]
ChEMBL Inhibition Assay: Six test compound concentrations (0.1, 0.25, 1, 2.5, 10, 25 μM in DMSO; final DMSO concentration=0.3%) are incubated with human liver microsomes (0.25 mg/mL) and NADPH (1 mM) in the presence of the probe substrate ethoxyresorufin (0.5 μM) for 5 min at 37° C. The selective CYP1A inhibitor, alpha-naphthoflavone, is screened alongside the test compounds as a positive control. B 4.6 pIC50 >25000 nM IC50 US-9333197-B2. Apoptosis signal-regulating kinase inhibitor (2016)
Myoglobin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2406892] [UniProtKB: P02144]
ChEMBL Inhibition of myoglobin (unknown origin)-mediated arachidonic acid oxidation using [14C]AA as substrate after 3 hrs by GC/NICI/MS analysis B 5.64 pIC50 2300 nM IC50 ACS Med. Chem. Lett. (2013) 4: 710-714 [PMID:24482730]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiparasitic activity against chloroquine-resistant Plasmodium falciparum K1 F 4.06 pIC50 86700 nM IC50 J. Med. Chem. (2008) 51: 1260-1277 [PMID:18260613]
COX-1 in Human [GtoPdb: 1375] [UniProtKB: P23219]
GtoPdb - - 3.94 pKi 113600 nM Ki FASEB J (2008) 22: 383-90 [PMID:17884974]
COX-2 in Human [GtoPdb: 1376] [UniProtKB: P35354]
GtoPdb - - 4.59 pKi 25800 nM Ki FASEB J (2008) 22: 383-90 [PMID:17884974]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]