carbonic anhydrase 7 | Carbonic anhydrases | IUPHAR/BPS Guide to PHARMACOLOGY

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carbonic anhydrase 7

Target not currently curated in GtoImmuPdb

Target id: 2749

Nomenclature: carbonic anhydrase 7

Abbreviated Name: CA VII

Family: Carbonic anhydrases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 264 16q22.1 CA7 carbonic anhydrase 7
Mouse - 264 8 D1 Car7 carbonic anhydrase 7
Rat - 264 19p14 Car7 carbonic anhydrase 7
Previous and Unofficial Names
carbonic anhydrase VII
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
histamine Hs Activation - - 3
KA 37500 nM. [3]
L-histidine Hs Activation - - 5
amphetamine Hs Activation - - 3
KA 910 nM. [3]
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ethoxzolamide Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 8x10-10 M) [2]
topiramate Hs Inhibition 9.1 pKi 2
pKi 9.1 (Ki 9x10-10 M) [2]
methazolamide Hs Inhibition 8.7 pKi 2
pKi 8.7 (Ki 2.1x10-9 M) [2]
acetazolamide Hs Inhibition 8.6 pKi 1
pKi 8.6 (Ki 2.5x10-9 M) [1]
brinzolamide Hs Inhibition 8.6 pKi 2
pKi 8.6 (Ki 2.8x10-9 M) [2]
chlorthalidone Hs Inhibition 8.6 pKi 4
pKi 8.6 (Ki 2.8x10-9 M) [4]
dorzolamide Hs Inhibition 8.5 pKi 2
pKi 8.5 (Ki 3.5x10-9 M) [2]
zonisamide Hs Inhibition 6.9 pKi 2
pKi 6.9 (Ki 1.17x10-7 M) [2]
indisulam Hs Inhibition 6.9 pKi 2
pKi 6.9 (Ki 1.22x10-7 M) [2]
sulpiride Hs Inhibition 5.4 pKi 2
pKi 5.4 (Ki 3.63x10-6 M) [2]
Inhibitor Comments
Carbonic anhydrase (CA) inhibitors are active over a number of CA isozymes. We tag those isozymes with the highest drug affinity as the primary molecular target of each of the drugs, with the caveat that the drugs interact with other CA isozymes.


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1. Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R. (2010) Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors. Bioorg. Med. Chem. Lett., 20 (15): 4376-81. [PMID:20605094]

2. Sethi KK, Vullo D, Verma SM, Tanç M, Carta F, Supuran CT. (2013) Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety. Bioorg. Med. Chem., 21 (19): 5973-82. [PMID:23965175]

3. Tanini D, Capperucci A, Supuran CT, Angeli A. (2019) Sulfur, selenium and tellurium containing amines act as effective carbonic anhydrase activators. Bioorg. Chem., 87: 516-522. [PMID:30928874]

4. Temperini C, Cecchi A, Scozzafava A, Supuran CT. (2009) Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference. Bioorg. Med. Chem., 17 (3): 1214-21. [PMID:19119014]

5. Temperini C, Scozzafava A, Vullo D, Supuran CT. (2006) Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme. Chemistry, 12 (27): 7057-66. [PMID:16807956]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 7. Last modified on 25/07/2019. Accessed on 30/03/2020. IUPHAR/BPS Guide to PHARMACOLOGY,