chlorthalidone   Click here for help

GtoPdb Ligand ID: 7147

Synonyms: G-33182 | Hygroton®
Approved drug
chlorthalidone is an approved drug (FDA (1960), UK (1998))
Compound class: Synthetic organic
Comment: Chlorthalidone is a thiazide-like diuretic. It has a longer duration of action than other thiazide drugs.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 121.36
Molecular weight 338.01
XLogP 1.87
No. Lipinski's rules broken 0
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Canonical SMILES Clc1ccc(cc1S(=O)(=O)N)C1(O)N=C(c2c1cccc2)O
Isomeric SMILES Clc1ccc(cc1S(=O)(=O)N)C1(O)N=C(c2c1cccc2)O
InChI InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1960), UK (1998))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
1125 chlortalidone
Synonyms Click here for help
G-33182 | Hygroton®
Database Links Click here for help
CAS Registry No. 77-36-1
ChEMBL Ligand CHEMBL1055
DrugBank Ligand DB00310
DrugCentral Ligand 625
GtoPdb PubChem SID 178103722
PubChem CID 2732
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UniChem Compound Search for chemical match using the InChIKey JIVPVXMEBJLZRO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey JIVPVXMEBJLZRO-UHFFFAOYSA-N
Wikipedia Chlortalidone