chlorthalidone   Click here for help

GtoPdb Ligand ID: 7147

Synonyms: G-33182 | Hygroton®
Approved drug
chlorthalidone is an approved drug (FDA (1960), UK (1998))
Compound class: Synthetic organic
Comment: Chlorthalidone is a thiazide-like diuretic. It has a longer duration of action than other thiazide drugs.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 121.36
Molecular weight 338.01
XLogP 1.87
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES Clc1ccc(cc1S(=O)(=O)N)C1(O)N=C(c2c1cccc2)O
Isomeric SMILES Clc1ccc(cc1S(=O)(=O)N)C1(O)N=C(c2c1cccc2)O
InChI InChI=1S/C14H11ClN2O4S/c15-11-6-5-8(7-12(11)22(16,20)21)14(19)10-4-2-1-3-9(10)13(18)17-14/h1-7,19H,(H,17,18)(H2,16,20,21)
InChI Key JIVPVXMEBJLZRO-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1960), UK (1998))
IUPAC Name Click here for help
2-chloro-5-(1,3-dihydroxy-1H-isoindol-1-yl)benzene-1-sulfonamide
International Nonproprietary Names Click here for help
INN number INN
1125 chlortalidone
Synonyms Click here for help
G-33182 | Hygroton®
Database Links Click here for help
CAS Registry No. 77-36-1
ChEMBL Ligand CHEMBL1055
DrugBank Ligand DB00310
DrugCentral Ligand 625
GtoPdb PubChem SID 178103722
PubChem CID 2732
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Wikipedia Chlortalidone