carbonic anhydrase 2 | Carbonic anhydrases | IUPHAR/BPS Guide to PHARMACOLOGY

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carbonic anhydrase 2

Target not currently curated in GtoImmuPdb

Target id: 3092

Nomenclature: carbonic anhydrase 2

Abbreviated Name: CA II

Family: Carbonic anhydrases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 260 8q21.2 CA2 carbonic anhydrase 2
Mouse - 260 Ch 3, 3.23 cM; 3 A1 Car2 carbonic anhydrase 2
Rat - 260 2q23 Car2 carbonic anhydrase 2
Gene and Protein Information Comments
Two transcript variants encoding different isoforms have been identified for the human and mouse genes.
Previous and Unofficial Names
CAII | Car2 | carbonic anhydrase II
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 4.2.1.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5a [PMID: 31287314] Hs Inhibition 7.0 pKi 1
pKi 7.0 (Ki 9.65x10-8 M) [1]
compound 5b [PMID: 31287314] Hs Inhibition 6.7 pKi 1
pKi 6.7 (Ki 2.154x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0030316 osteoclast differentiation TAS
click arrow to show/hide IEA associations
GO:0045672 positive regulation of osteoclast differentiation IEA

References

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1. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J. Med. Chem., 62 (15): 7233-7249. [PMID:31287314]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 2. Last modified on 24/07/2019. Accessed on 01/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3092.