Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	260	8q21.2	CA2	carbonic anhydrase 2
Mouse	-	260	3 3.23 cM	Car2	carbonic anhydrase 2
Rat	-	260	2q23	Car2	carbonic anhydrase 2
Gene and Protein Information Comments
Two transcript variants encoding different isoforms have been identified for the human and mouse genes.

Previous and Unofficial Names

CAII | Car2 | carbonic anhydrase II

Database Links
Alphafold	P00918 (Hs), P00920 (Mm), P27139 (Rn)
BRENDA	4.2.1.1
ChEMBL Target	CHEMBL205 (Hs), CHEMBL3689 (Mm), CHEMBL4706 (Rn)
Ensembl Gene	ENSG00000104267 (Hs), ENSMUSG00000027562 (Mm), ENSRNOG00000009629 (Rn)
Entrez Gene	760 (Hs), 12349 (Mm), 54231 (Rn)
Human Protein Atlas	ENSG00000104267 (Hs)
KEGG Enzyme	4.2.1.1
KEGG Gene	hsa:760 (Hs), mmu:12349 (Mm), rno:54231 (Rn)
OMIM	611492 (Hs)
Pharos	P00918 (Hs)
RefSeq Nucleotide	NM_000067 (Hs), NM_009801 (Mm), NM_019291 (Rn)
RefSeq Protein	NP_000058 (Hs), NP_033931 (Mm), NP_062164 (Rn)
UniProtKB	P00918 (Hs), P00920 (Mm), P27139 (Rn)
Wikipedia	CA2 (Hs)

Enzyme Reaction
EC Number: 4.2.1.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference compound 5a [PMID: 31287314] Hs Inhibition 7.0 pKi 1 ⤷ pKi 7.0 (Ki 9.65x10-8 M) [1] compound 5b [PMID: 31287314] Hs Inhibition 6.7 pKi 1 ⤷ pKi 6.7 (Ki 2.154x10-7 M) [1] salvianolic acid A Hs Inhibition 5.0 pKi 2 ⤷ pKi 5.0 (Ki 9.594x10-6 M) [2]

Immuno Process Associations

Immuno Process:  Immune regulation

Immuno Process:  Immune system development