carbonic anhydrase 2 | Carbonic anhydrases | IUPHAR/BPS Guide to PHARMACOLOGY

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carbonic anhydrase 2

Target not currently curated in GtoImmuPdb

Target id: 3092

Nomenclature: carbonic anhydrase 2

Abbreviated Name: CA II

Family: Carbonic anhydrases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 260 8q21.2 CA2 carbonic anhydrase 2
Mouse - 260 Ch 3, 3.23 cM; 3 A1 Car2 carbonic anhydrase 2
Rat - 260 2q23 Car2 carbonic anhydrase 2
Gene and Protein Information Comments
Two transcript variants encoding different isoforms have been identified for the human and mouse genes.
Previous and Unofficial Names
CAII | Car2 | carbonic anhydrase II
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 5a [PMID: 31287314] Hs Inhibition 7.0 pKi 1
pKi 7.0 (Ki 9.65x10-8 M) [1]
compound 5b [PMID: 31287314] Hs Inhibition 6.7 pKi 1
pKi 6.7 (Ki 2.154x10-7 M) [1]
Immuno Process Associations
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045672 positive regulation of osteoclast differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes, IEA only
GO:0030316 osteoclast differentiation TAS
click arrow to show/hide IEA associations
GO:0045672 positive regulation of osteoclast differentiation IEA


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1. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J. Med. Chem., 62 (15): 7233-7249. [PMID:31287314]

How to cite this page

Carbonic anhydrases: carbonic anhydrase 2. Last modified on 24/07/2019. Accessed on 01/04/2020. IUPHAR/BPS Guide to PHARMACOLOGY,