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Target not currently curated in GtoImmuPdb
Target id: 3055
Nomenclature: carbonic anhydrase 9
Abbreviated Name: CA IX
Family: Carbonic anhydrases
Gene and Protein Information  |
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| Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 1 | 459 | 9p13.3 | CA9 | carbonic anhydrase 9 | 4-5 |
| Mouse | 1 | 437 | 4 A5 | Car9 | carbonic anhydrase 9 | |
| Rat | 1 | 437 | 5q22 | Car9 | carbonic anhydrase 9 | |
| Previous and Unofficial Names |
| Car9 | Ca9 | CAIX | carbonic anhydrase IX |
| Database Links |
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| Alphafold | Q16790 (Hs), Q8VHB5 (Mm) |
| BRENDA | 4.2.1.1 |
| ChEMBL Target | CHEMBL3594 (Hs) |
| Ensembl Gene | ENSG00000107159 (Hs), ENSMUSG00000028463 (Mm), ENSRNOG00000017073 (Rn) |
| Entrez Gene | 768 (Hs), 230099 (Mm), 313495 (Rn) |
| Human Protein Atlas | ENSG00000107159 (Hs) |
| KEGG Enzyme | 4.2.1.1 |
| KEGG Gene | hsa:768 (Hs), mmu:230099 (Mm), rno:313495 (Rn) |
| OMIM | 603179 (Hs) |
| Pharos | Q16790 (Hs) |
| RefSeq Nucleotide | NM_139305 (Hs), NM_139305 (Mm), NM_001107956 (Rn) |
| RefSeq Protein | NP_001207 (Hs), NP_647466 (Mm), NP_001101426 (Rn) |
| UniProtKB | Q16790 (Hs), Q8VHB5 (Mm) |
| Wikipedia | CA9 (Hs) |
| Enzyme Reaction |
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Download all structure-activity data for this target as a CSV file 
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Tissue Distribution Comments | |
| CA IX is one of two known tumour-associated carbonic anhydrase isoenzymes, the other being CA XII, where it is associated with cell proliferation, transformation and metastasis. It is not detected in most normal tissues. |
| General Comments |
| CA IX is a membrane anchored carbonic anhydrase, and is one of two known tumour-associated carbonic anhydrase isoenzymes, the other being CA XII. Its activity in the hypoxic tumour microenvironment is associated with mechanisms that support cell proliferation, transformation and metastasis. |
1. Berrino E, Milazzo L, Micheli L, Vullo D, Angeli A, Bozdag M, Nocentini A, Menicatti M, Bartolucci G, di Cesare Mannelli L et al.. (2019) Synthesis and Evaluation of Carbonic Anhydrase Inhibitors with Carbon Monoxide Releasing Properties for the Management of Rheumatoid Arthritis. J Med Chem, 62 (15): 7233-7249. [PMID:31287314]
2. Carta F, Maresca A, Scozzafava A, Supuran CT. (2012) 5- and 6-membered (thio)lactones are prodrug type carbonic anhydrase inhibitors. Bioorg Med Chem Lett, 22 (1): 267-70. [PMID:22137345]
3. Congiu C, Onnis V, Deplano A, Balboni G, Dedeoglu N, Supuran CT. (2015) Synthesis of sulfonamides incorporating piperazinyl-ureido moieties and their carbonic anhydrase I, II, IX and XII inhibitory activity. Bioorg Med Chem Lett, 25 (18): 3850-3. [PMID:26233435]
4. Nakagawa Y, Uemura H, Hirao Y, Yoshida K, Saga S, Yoshikawa K. (1998) Radiation hybrid mapping of the human MN/CA9 locus to chromosome band 9p12-p13. Genomics, 53 (1): 118-9. [PMID:9787087]
5. Opavský R, Pastoreková S, Zelník V, Gibadulinová A, Stanbridge EJ, Závada J, Kettmann R, Pastorek J. (1996) Human MN/CA9 gene, a novel member of the carbonic anhydrase family: structure and exon to protein domain relationships. Genomics, 33 (3): 480-7. [PMID:8661007]
Carbonic anhydrases: carbonic anhydrase 9. Last modified on 04/12/2024. Accessed on 07/12/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=3055.
