adenosine-3'-5'-bisphosphate [Ligand Id: 1718] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL574817
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  • P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
P2Y purinoceptor 1 in Turkey (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5720] [UniProtKB: P49652]
ChEMBL In vitro antagonist activity at P2Y1 receptor in turkey erythrocyte membranes. F 4.83 pIC50 14900 nM IC50 J. Med. Chem. (1999) 42: 1625-1638 [PMID:10229631]
ChEMBL Antagonist activity at P2Y1 receptor measured as capacity to inhibit 50% of phospholipase C stimulation elicited by 10 nM 2-MeSATP F 5.38 pIC50 4190 nM IC50 J. Med. Chem. (1998) 41: 183-190 [PMID:9457242]
ChEMBL Concentration at which 50% of the maximal effect (stimulation of PLC at P2Y1 receptor in the turkey erythrocyte membranes) is reached F 5.63 pEC50 2340 nM EC50 J. Med. Chem. (1999) 42: 1625-1638 [PMID:10229631]
ChEMBL Agonist activity at P2Y1 receptor measured as capacity to stimulate 50% phospholipase C in turkey erythrocyte membranes F 5.89 pEC50 1280 nM EC50 J. Med. Chem. (1998) 41: 183-190 [PMID:9457242]
P2Y1 receptor in Human [GtoPdb: 323] [UniProtKB: P47900]
GtoPdb - - 5.6 pEC50 - - - Mol Pharmacol (1996) 50: 1323-9 [PMID:8913364]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]