Compound class:
Synthetic organic
Comment: HT1042 is reported to inhibit the β5i component of the 20S proteasome complex [1], which is constitutively expressed in dendritic cells and lymphocytes, and is induced in other cells by some cytokines to modulate antigen presentation [2]. Inhibitors selective for this immune system-associated 20S proteasome complex are expected to provide novel and more selective anti-inflammatory leads, compared to the current broad-spectrum proteasome inhibitor bortezomib used in the clinic.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
5-(3-nitrophenyl)-1,3,4-oxathiazol-2-one |
Database Links ![]() |
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CAS Registry No. | 23589-77-7 (source: PubChem) |
ChEMBL Ligand | CHEMBL3265177 |
GtoPdb PubChem SID | 252166849 |
PubChem CID | 325597 |
Search Google for chemical match using the InChIKey | QBAZATRGWRVUFN-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | QBAZATRGWRVUFN |
UniChem Compound Search for chemical match using the InChIKey | QBAZATRGWRVUFN-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | QBAZATRGWRVUFN-UHFFFAOYSA-N |