ChEMBL ligand: CHEMBL1438439
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332] There should be some charts here, you may need to enable JavaScript!
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
RTP Type S/Receptor-type tyrosine-protein phosphatase S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2396508] [GtoPdb: 1866] [UniProtKB: Q13332]
ChEMBL	Inhibition of recombinant human PTP-sigma (residues 1367 to 1948) using para-nitrophenylphosphate as substrate for 60 mins by fluorescence analysis	B	6.3	pIC50	500	nM	IC50	Bioorg Med Chem Lett (2016) 26: 87-93 [PMID:26602279]
regulator of G-protein signaling 17/Regulator of G-protein signaling 17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295974] [GtoPdb: 2801] [UniProtKB: Q9UGC6]
ChEMBL	Binding affinity to RGS17 (unknown origin) by ITC assay	B	6.15	pKd	714	nM	Kd	US-20160264616-A1. Therapeutic compounds and methods (null)
ChEMBL	Inhibition of RGS17 (unknown origin) C117A mutant interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4.09	pIC50	81800	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of wild type GST-tagged RGS17 (unknown origin) interaction with biotinylated Galphao after 30 mins in presence of AMF and GDP by AlphaScreen assay	B	4.33	pIC50	47200	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
GtoPdb	-	-	4.33	pIC50	47200	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) in presence of and ATP Galpha-o by Malachite green steady-state GTPase assay	B	4.45	pIC50	35510	nM	IC50	US-20160264616-A1. Therapeutic compounds and methods (null)
ChEMBL	Inhibition of RGS17 (unknown origin) GAP activity in presence of GTP by malachite green dye based assay	B	4.46	pIC50	35000	nM	IC50	J Nat Prod (2017) 80: 1992-2000 [PMID:28621943]
ChEMBL	Inhibition of RGS17 (unknown origin) assessed as reduction in RGS17 interaction with 6x-his-tagged biotinylated Galpha-o interaction by Alpha-screen assay	B	6.37	pIC50	423.2	nM	IC50	US-20160264616-A1. Therapeutic compounds and methods (null)

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]