Ligand id: 573

Name: C5a

Species: Human

Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Complement components and ligands
C5a anaphylatoxin | complement component C5a | human complement protein
C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Gene symbol Gene name Species Precursor protein name Synonyms
C5 complement C5 Human prepro-C5 complement component 5, CPAMD4
Database Links
CAS Registry No. 80295-54-1 (Hs)
DrugBank Target P01031 (Hs)
GtoPdb PubChem SID 135651643
UniProtKB P01031 (Hs)
Wikipedia Complement_component_5a