C5a   

GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
References
1. Ames RS, Nuthulaganti P, Kumar C. (1996)
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.
FEBS Lett., 395 (2-3): 157-9. [PMID:8898085]
2. Cain SA, Monk PN. (2002)
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).
J. Biol. Chem., 277 (9): 7165-9. [PMID:11773063]
3. Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C et al.. (2009)
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
Am. J. Respir. Crit. Care Med., 180 (1): 19-28. [PMID:19324972]
4. Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JD, Taylor SM, Fairlie DP, Monk PN. (2005)
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.
J Biol Chem, 280: 17831-17840. [PMID:15661745]
5. Manthey HD, Woodruff TM, Taylor SM, Monk PN. (2009)
Complement component 5a (C5a).
Int. J. Biochem. Cell Biol., 41 (11): 2114-7. [PMID:19464229]
6. Nishiura H, Shibuya Y, Yamamoto T. (1998)
S19 ribosomal protein cross-linked dimer causes monocyte-predominant infiltration by means of molecular mimicry to complement C5a.
Lab. Invest., 78 (12): 1615-23. [PMID:9881961]
7. Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP et al.. (2003)
C5L2, a nonsignaling C5A binding protein.
Biochemistry, 42 (31): 9406-15. [PMID:12899627]
8. Paczkowski NJ, Finch AM, Whitmore JB, Short AJ, Wong AK, Monk PN, Cain SA, Fairlie DP, Taylor SM. (1999)
Pharmacological characterization of antagonists of the C5a receptor.
Br. J. Pharmacol., 128 (7): 1461-6. [PMID:10602324]