C5a   Click here for help

GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Immunopharmacology Ligand
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
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1. Ames RS, Nuthulaganti P, Kumar C. (1996)
In Xenopus oocytes the human C3a and C5a receptors elicit a promiscuous response to the anaphylatoxins.
FEBS Lett, 395 (2-3): 157-9. [PMID:8898085]
2. Cain SA, Monk PN. (2002)
The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).
J Biol Chem, 277 (9): 7165-9. [PMID:11773063]
3. Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C et al.. (2009)
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.
Am J Respir Crit Care Med, 180 (1): 19-28. [PMID:19324972]
4. Higginbottom A, Cain SA, Woodruff TM, Proctor LM, Madala PK, Tyndall JD, Taylor SM, Fairlie DP, Monk PN. (2005)
Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.
J Biol Chem, 280: 17831-17840. [PMID:15661745]
5. Manthey HD, Woodruff TM, Taylor SM, Monk PN. (2009)
Complement component 5a (C5a).
Int J Biochem Cell Biol, 41 (11): 2114-7. [PMID:19464229]
6. Nishiura H, Shibuya Y, Yamamoto T. (1998)
S19 ribosomal protein cross-linked dimer causes monocyte-predominant infiltration by means of molecular mimicry to complement C5a.
Lab Invest, 78 (12): 1615-23. [PMID:9881961]
7. Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP et al.. (2003)
C5L2, a nonsignaling C5A binding protein.
Biochemistry, 42 (31): 9406-15. [PMID:12899627]
8. Paczkowski NJ, Finch AM, Whitmore JB, Short AJ, Wong AK, Monk PN, Cain SA, Fairlie DP, Taylor SM. (1999)
Pharmacological characterization of antagonists of the C5a receptor.
Br J Pharmacol, 128 (7): 1461-6. [PMID:10602324]