GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
Natural/Endogenous Targets
C3a receptor
C5a1 receptor
C5a2 receptor
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
C5a2 receptor Hs Agonist Full agonist 8.9 pEC50 -
pEC50 8.9 (EC50 1.4x10-9 M)
C5a1 receptor Hs Agonist Full agonist 8.0 – 9.0 pEC50 - 6,8
pEC50 8.0 – 9.0 (EC50 1x10-8 – 1x10-9 M) [6,8]
C5a1 receptor Hs Agonist Full agonist 9.1 – 9.2 pIC50 - 4,8
pIC50 9.1 – 9.2 [4,8]
C5a2 receptor Hs Agonist Full agonist 8.0 – 8.6 pIC50 - 2,7
pIC50 8.0 – 8.6 (IC50 9.5x10-9 – 2.5x10-9 M) [2,7]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields