Top ▲

Complement peptide receptors C

Formerly known as: Anaphylatoxin receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide More detailed introduction

Complement peptide receptors (nomenclature as agreed by the NC-IUPHAR subcommittee on Complement peptide receptors [22]) are activated by the endogenous ~75 amino-acid anaphylatoxin polypeptides C3a (C3, P01024) and C5a (C5, P01031), generated upon stimulation of the complement cascade. C3a and C5a exert their functions through binding to their receptors (C3aR and C5aR), causing cell activation and triggering cellular degranulation that contributes to the local inflammation.

Receptors

C3a receptor C Show summary » More detailed page

C5a1 receptor C Show summary » More detailed page

C5a2 receptor C Show summary » More detailed page

Comments

Show »

Further reading

Show »

References

Show »

NC-IUPHAR subcommittee and family contributors

Show »

How to cite this family page

Database page citation:

Peter Monk, Antonia Cianciulli, Liam Coulthard, Owen Hawksworth, John D. Lee, Vincenzo Mitolo, Maria A. Panaro, Trent M. Woodruff. Complement peptide receptors. Accessed on 25/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=5.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Christopoulos A, Davenport AP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: G protein-coupled receptors. Br J Pharmacol. 174 Suppl 1: S17-S129.