C5a   Click here for help

GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Immunopharmacology Ligand
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Complement components and ligands
Synonyms Click here for help
C5a anaphylatoxin | complement component C5a | human complement protein
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
C5 complement C5 Human prepro-C5 complement component 5, CPAMD4
Database Links Click here for help
Specialist databases
GPCRdb Ligand C5a
Other databases
CAS Registry No. 80295-54-1 (Hs)
DrugBank Target P01031 (Hs)
Ensembl Gene ENSG00000106804 (Hs)
GtoPdb PubChem SID 135651643
Human Protein Atlas ENSG00000106804 (Hs)
UniProtKB P01031 (Hs)
Wikipedia Complement_component_5a