Ligand id: 573

Name: C5a

Species: Human

Immunopharmacology Comments
Complement component C5a is cleaved from C5 by the protease C5-convertase. C5a exerts pro-inflammatory effects that are mediated via complement activation, formation of the membrane attack complex (MAC), attraction of innate immune cells, and induction of histamine release. Elevated production of C5a is associated with a number of inflammatory diseases [5].
Immunopharmacology Disease
Disease X-Refs Comment References
Sepsis C5a has been shown to impair phagocytic function and migration of peripheral blood neutrophils isolated from critically ill patients. 3