C5a   

GtoPdb Ligand ID: 573

Synonyms: C5a anaphylatoxin | complement component C5a | human complement protein
Comment: C5a is the ligand for the GPCR, C5a receptor (CD88) that is expressed by macrophages, neutrophils and endothelial cells. C5a is a potent inflammatory agent that is a key mediator involved in the pathogenesis of a number of inflammatory diseases involving the complement system (sepsis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythemotosis and psoriasis for example).
Species: Human
Immunopharmacology Comments
Complement component C5a is cleaved from C5 by the protease C5-convertase. C5a exerts pro-inflammatory effects that are mediated via complement activation, formation of the membrane attack complex (MAC), attraction of innate immune cells, and induction of histamine release. Elevated production of C5a is associated with a number of inflammatory diseases [5].
Immunopharmacology Disease
Disease X-Refs Comment References
Sepsis C5a has been shown to impair phagocytic function and migration of peripheral blood neutrophils isolated from critically ill patients. 3