SANT-1 [Ligand Id: 10330] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL515916 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| SMO/Smoothened homolog in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5971] [GtoPdb: 239] [UniProtKB: Q99835] | ||||||||
| ChEMBL | Inhibition of Smoothened transfected in HEK293 cells by binding assay | B | 7.6 | pIC50 | 25 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4932-4935 [PMID:20620058] |
| ChEMBL | Inhibition of Smoothened transfected in HEK293 cells by transient transfection cell-based assay | B | 8.32 | pIC50 | 4.74 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4932-4935 [PMID:20620058] |
| SMO in Mouse [GtoPdb: 239] [UniProtKB: P56726] | ||||||||
| GtoPdb | In Gli-dependent reporter assays in Shh-LIGHT2 cells. | - | 7.7 | pKi | 20 | nM | Ki | Proc Natl Acad Sci USA (2002) 99: 14071-6 [PMID:12391318] |
| Sonic hedgehog protein in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5387] [UniProtKB: Q62226] | ||||||||
| ChEMBL | Inhibition of SHH-mediated mouse C3H10T1/2 cells differentiation into osteoblasts by alkaline phosphatase assay | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2009) 52: 3829-3845 [PMID:19309080] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
