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Compound class:
Endogenous peptide in human, mouse or rat
Comment: ICAM-1 is a cell-adhesion molecule that is overexpressed on the surface of a number of cancer cells types [1,5], and this may be correlated with metastasis and poor prognosis [3]. These findings suggest ICAM-1 as an ideal target for oncology therapeutic development [2]. Monoclonal antibodies (and antibody-drug conjugates) that target ICAM-1 are being explored for anti-tumour potential [4,6-7], and there is a report of the experimental effect of ICAM-1 targeting CAR-T cells in triple-negative breast cancer [8].
Species: Human
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Classification  |
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| Compound class | Endogenous peptide in human, mouse or rat |
| Ligand families/groups | CD molecules (ligands) |
| Gene/Precursor |
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| Database Links |
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| CATH/Gene3D | 2.60.40.10 |
| DrugBank Target | P05362 (Hs) |
| Ensembl Gene | ENSG00000090339 (Hs) |
| Entrez Gene | 3383 (Hs) |
| GtoPdb PubChem SID | 178103368 |
| Human Protein Atlas | ENSG00000090339 (Hs) |
| Immunopaedia Search | ICAM-1 |
| UniProtKB | P05362 (Hs) |
| Wikipedia | ICAM1 |
