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ChEMBL ligand: CHEMBL1213327 (CoASH, Coenzyme_a, Coenzyme A) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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choline O-acetyltransferase/Choline acetylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4039] [GtoPdb: 2480] [UniProtKB: P28329] | ||||||||
ChEMBL | Inhibition of choline acetyltransferase isolated from squid head ganglia | B | 4.12 | pKi | 75000 | nM | Ki | J Med Chem (1981) 24: 1534-1537 [PMID:7310833] |
lysine acetyltransferase 5/Histone acetyltransferase KAT5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5750] [GtoPdb: 2664] [UniProtKB: Q92993] | ||||||||
ChEMBL | Inhibition of recombinant Tip60 (1-513) expressed in Escherichia coli BL21 (DE3) by liquid scintillation | B | 4.08 | pIC50 | 82270 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
E1A binding protein p300/Histone acetyltransferase p300 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3784] [GtoPdb: 2735] [UniProtKB: Q09472] | ||||||||
ChEMBL | Inhibition of recombinant p300 | B | 4.34 | pIC50 | 45940 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
lysine acetyltransferase 2B/Histone acetyltransferase PCAF in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5500] [GtoPdb: 2737] [UniProtKB: Q92831] | ||||||||
ChEMBL | Inhibition of PCAF HAT domain (493-658) expressed in Escherichia coli BL21 (DE3) | B | 4.38 | pIC50 | 41910 | nM | IC50 | Bioorg Med Chem (2009) 17: 1381-1386 [PMID:19114310] |
N-alpha-acetyltransferase 50 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4630854] [UniProtKB: Q9GZZ1] | ||||||||
ChEMBL | Binding affinity to full length human N-terminal His-tagged/GST-tagged Naa50 expressed in Escherichia coli BL21(DE3) cells in by SPR analysis | B | 6.81 | pKd | 156 | nM | Kd | ACS Med Chem Lett (2020) 11: 1175-1184 [PMID:32550998] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]