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choline O-acetyltransferase

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Target not currently curated in GtoImmuPdb

Target id: 2480

Nomenclature: choline O-acetyltransferase

Abbreviated Name: ChAT

Family: Acetylcholine turnover

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 748 10q11.23 CHAT choline O-acetyltransferase
Mouse - 641 14 19.4 cM Chat choline acetyltransferase
Rat - 640 16p16 Chat choline O-acetyltransferase
Previous and Unofficial Names Click here for help
CHOACTase | Choline acetylase
Database Links Click here for help
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 2.3.1.6 Acetyl CoA + choline = acetylcholine + coenzyme A

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
naphthylvinylmethylpyridine Small molecule or natural product Mm Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3.4x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology Click here for help
Disease:  Myasthenic syndrome, congenital, 6, presynaptic; CMS6
Synonyms: Congenital myasthenic syndrome [Disease Ontology: DOID:3635] [Orphanet: ORPHA590]
Presynaptic congenital myasthenic syndromes [Orphanet: ORPHA98914]
Disease Ontology: DOID:3635
OMIM: 254210
Orphanet: ORPHA98914, ORPHA590

References

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1. Gray AP, Platz RD, Henderson TR, Chang TC, Takahashi K, Dretchen KL. (1988) Approaches to protection against nerve agent poisoning. (Naphthylvinyl)pyridine derivatives as potential antidotes. J Med Chem, 31 (4): 807-14. [PMID:3351860]

How to cite this page

Acetylcholine turnover: choline O-acetyltransferase. Last modified on 07/06/2021. Accessed on 28/01/2022. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2480.