Gene and Protein Information
Species	TM	AA	Chromosomal Location	Gene Symbol	Gene Name	Reference
Human	-	748	10q11.23	CHAT	choline O-acetyltransferase
Mouse	-	641	14 19.4 cM	Chat	choline O-acetyltransferase
Rat	-	640	16p16	Chat	choline O-acetyltransferase

Previous and Unofficial Names

CHOACTase | Choline acetylase | choline acetyltransferase

Database Links
Alphafold	P28329 (Hs), Q03059 (Mm), P32738 (Rn)
BRENDA	2.3.1.6
ChEMBL Target	CHEMBL4039 (Hs), CHEMBL5900 (Mm), CHEMBL3945 (Rn)
Ensembl Gene	ENSG00000070748 (Hs), ENSMUSG00000021919 (Mm), ENSRNOG00000025012 (Rn)
Entrez Gene	1103 (Hs), 12647 (Mm), 290567 (Rn)
Human Protein Atlas	ENSG00000070748 (Hs)
KEGG Enzyme	2.3.1.6
KEGG Gene	hsa:1103 (Hs), mmu:12647 (Mm), rno:290567 (Rn)
OMIM	118490 (Hs)
Pharos	P28329 (Hs)
RefSeq Nucleotide	NM_020549 (Hs), NM_009891 (Mm), NM_001170593 (Rn)
RefSeq Protein	NP_065574 (Hs), NP_034021 (Mm), NP_001164064 (Rn)
UniProtKB	P28329 (Hs), Q03059 (Mm), P32738 (Rn)
Wikipedia	CHAT (Hs)

Enzyme Reaction
EC Number: 2.3.1.6 Acetyl CoA + choline = acetylcholine + coenzyme A

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols	View all chemical structures	Click column headers to sort
Ligand Sp. Action Value Parameter Reference naphthylvinylmethylpyridine Mm Inhibition 6.5 pIC50 1 ⤷ pIC50 6.5 (IC50 3.4x10-7 M) [1]

Clinically-Relevant Mutations and Pathophysiology
Disease:  Myasthenic syndrome, congenital, 6, presynaptic; CMS6 Synonyms: Congenital myasthenic syndrome [Disease Ontology: DOID:3635] [Orphanet: ORPHA590] Presynaptic congenital myasthenic syndromes [Orphanet: ORPHA98914] Disease Ontology: DOID:3635 OMIM: 254210 Orphanet: ORPHA98914, ORPHA590