ChEMBL ligand: CHEMBL3633460 (Pf-06282999)
myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL	Inhibition of peroxidase activity of MPO isolated from human polynuclear leukocytes using Amplex Red as substrate assessed as formation of resorufin measured every 20 secs by spectrophotometric analysis	B	6.5	pKi	316.23	nM	Ki	J Med Chem (2015) 58: 8513-8528 [PMID:26509551]
GtoPdb	Inhibition of the peroxidase activity of MPO isolated from human polynuclear leukocytes.	-	6.5	pKi	316	nM	Ki	J Med Chem (2015) 58: 8513-28 [PMID:26509551]
ChEMBL	Irreversible inhibition of MPO in LPS-stimulated human whole blood after 4 hrs by Amplex Red/H2O2-based fluorescence plate reader analysis	B	5.72	pIC50	1900	nM	IC50	J Med Chem (2015) 58: 8513-8528 [PMID:26509551]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]