captopril [Ligand Id: 5158] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1560 (Hyteneze 12.5, SQ-14225, Ecopace, Capoten, SQ -14225, Hyteneze 50, Kaplon, Noyada, SA-333, SQ 14,225, C09AA01, Tensobon, Hyteneze 25, Lopril, Acepril, Captomex, Captopril)
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  • Beta-lactamase VIM-2 in Pseudomonas aeruginosa [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
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  • Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
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  • Succinyl-diaminopimelate desuccinylase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [ChEMBL: CHEMBL1075192] [UniProtKB: P44514]
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  • coagulation factor II, thrombin/Thrombin in Human [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821]
GtoPdb - - 8.4 pKi 3.98 nM Ki Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274]
ChEMBL Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay B 8.7 pKi 2 nM Ki J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum B 5.89 pIC50 1300 nM IC50 J. Med. Chem. (1985) 28: 1291-1295 [PMID:2993618]
ChEMBL Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzyme B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1980) 23: 1392-1398 [PMID:6256550]
ChEMBL Compound was evaluated for inhibition of porcine plasma Angiotensin I converting enzyme by using fluorometric assay B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1985) 28: 1062-1066 [PMID:2991517]
ChEMBL Inhibition of angiotensin I converting enzyme in silico B 7.1 pIC50 79.43 nM IC50 J. Med. Chem. (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL Compound was tested for inhibitory activity against Angiotensin I converting enzyme B 7.52 pIC50 30 nM IC50 Bioorg. Med. Chem. Lett. (1993) 3: 1953-1958
ChEMBL In vitro inhibition of Angiotensin I converting enzyme in Hog plasma B 7.6 pIC50 25 nM IC50 J. Med. Chem. (1990) 33: 1606-1615 [PMID:2160536]
ChEMBL Inhibition of ACE (unknown origin) using hippuryl-L-histidyl-L-leucine as substrate preincubated with substrate for 30 mins followed by enzyme addition measured after 30 mins by LC/MS analysis B 7.6 pIC50 25 nM IC50 J Nat Prod (2018) 81: 349-355 [PMID:29405714]
ChEMBL Inhibition of ACE B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4529-4532 [PMID:18674901]
ChEMBL In vitro inhibition against angiotensin converting enzyme (ACE) B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 2673-2676
ChEMBL Inhibitory activity against angiotensin I converting enzyme (ACE) B 7.64 pIC50 23 nM IC50 J. Med. Chem. (2000) 43: 305-341 [PMID:10669559]
ChEMBL Inhibitory concentration against angiotensin I converting enzyme B 7.64 pIC50 23 nM IC50 J. Med. Chem. (2005) 48: 6523-6543 [PMID:16220969]
ChEMBL Inhibitory activity against angiotensin converting enzyme (ACE) F 7.64 pIC50 22.91 nM IC50 J. Med. Chem. (1993) 36: 2390-2403 [PMID:8360884]
ChEMBL Inhibition of angiotensin-converting enzyme (unknown origin) B 7.64 pIC50 22.91 nM IC50 MedChemComm (2012) 3: 1290-1293
ChEMBL Inhibition of human recombinant ACE/CD143 somatic form using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins prior to substrate addition measured for 30 mins by spectrophotometric analysis B 7.68 pIC50 21 nM IC50 J. Med. Chem. (2013) 56: 7997-8007 [PMID:24074025]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1985) 28: 434-442 [PMID:2984419]
ChEMBL Inhibition of Angiotensin I converting enzyme B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1985) 28: 393-399 [PMID:2983076]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1985) 28: 1603-1606 [PMID:2999394]
ChEMBL Inhibition of guinea pig angiotensin I converting enzyme B 7.89 pIC50 13 nM IC50 J. Med. Chem. (1986) 29: 1953-1961 [PMID:3020249]
ChEMBL Compound tested in vitro for inhibition of Angiotensin I converting enzyme B 7.89 pIC50 12.9 nM IC50 J. Med. Chem. (1989) 32: 1600-1606 [PMID:2544729]
ChEMBL Concentration required for 50% inhibition of Angiotensin I converting enzyme B 7.92 pIC50 12 nM IC50 J. Med. Chem. (1981) 24: 104-109 [PMID:6259352]
ChEMBL Inhibition of human ACE-mediated amyloid beta hydrolysis B 7.96 pIC50 11 nM IC50 Eur. J. Med. Chem. (2014) 79: 184-193 [PMID:24735644]
ChEMBL In vitro inhibitory concentration against angiotensin-converting enzyme B 8 pIC50 10 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 2715-2720
ChEMBL Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50% B 8.05 pIC50 9 nM IC50 J. Med. Chem. (1981) 24: 964-969 [PMID:6173481]
ChEMBL Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric method B 8.2 pIC50 6.3 nM IC50 J Med Chem (2018) 61: 3779-3798 [PMID:29039662]
ChEMBL Inhibition of ACE by fluorometric assay B 8.3 pIC50 5 nM IC50 J. Nat. Prod. (1988) 51: 357-359 [PMID:3379417]
ChEMBL Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated for 1 hr by colorimetric assay B 8.79 pIC50 1.61 nM IC50 J. Nat. Prod. (2015) 78: 1179-1183 [PMID:25922884]
ChEMBL Inhibition of human ACE B 9.2 pIC50 0.63 nM IC50 J. Med. Chem. (2008) 51: 4150-4169 [PMID:18588282]
ChEMBL Inhibition of human recombinant ACE by fluorimetry B 9.92 pIC50 0.12 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 4715-4719 [PMID:19596577]
ChEMBL Inhibition of human ACE C domain B 4.67 pEC50 21208.01 nM EC50 Bioorg. Med. Chem. Lett. (2006) 16: 5084-5087 [PMID:16889963]
ChEMBL Inhibition of human ACE K1087A mutant B 4.73 pEC50 18539.58 nM EC50 Bioorg. Med. Chem. Lett. (2006) 16: 5084-5087 [PMID:16889963]
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822]
ChEMBL Inhibitory activity against rabbit lung angiotensin-1 converting enzyme B 8.77 pKi 1.7 nM Ki J. Med. Chem. (1988) 31: 1148-1160 [PMID:2836590]
ChEMBL In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base B 5.62 pIC50 2400 nM IC50 Bioorg. Med. Chem. Lett. (1991) 1: 581-584
ChEMBL DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) B 6.89 pIC50 130 nM IC50 DrugMatrix in vitro pharmacology data
ChEMBL In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme B 7.57 pIC50 27 nM IC50 J. Med. Chem. (1985) 28: 57-66 [PMID:2981324]
ChEMBL In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrate B 7.64 pIC50 23 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 1783-1788
ChEMBL In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate B 7.64 pIC50 23 nM IC50 J. Med. Chem. (1988) 31: 204-212 [PMID:3336020]
ChEMBL Ability to inhibit Angiotensin I converting enzyme was determined B 7.64 pIC50 23 nM IC50 J. Med. Chem. (1984) 27: 816-818 [PMID:6330355]
ChEMBL In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme B 7.64 pIC50 23 nM IC50 J. Med. Chem. (1985) 28: 57-66 [PMID:2981324]
ChEMBL In vitro 50% inhibition of Angiotensin I converting enzyme B 7.66 pIC50 22 nM IC50 J. Med. Chem. (1988) 31: 875-885 [PMID:2832605]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme in rabbit lung, using hippuryl-histidyl-leucine as substrate B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1982) 25: 250-258 [PMID:6279843]
ChEMBL Inhibitory concentration against angiotensin converting enzyme (ACE) B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 2799-2804
ChEMBL In vitro inhibition of Angiotensin I converting enzyme in rabbit lung B 7.74 pIC50 18 nM IC50 J. Med. Chem. (1990) 33: 1606-1615 [PMID:2160536]
ChEMBL In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung B 7.77 pIC50 17 nM IC50 J. Med. Chem. (1986) 29: 784-796 [PMID:3009814]
ChEMBL In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 B 7.77 pIC50 17 nM IC50 J. Med. Chem. (1985) 28: 57-66 [PMID:2981324]
ChEMBL In vitro inhibition of angiotensin I converting enzyme (ACE) B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1983) 26: 1277-1282 [PMID:6310113]
ChEMBL In vitro inhibition of Angiotensin I converting enzyme B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1983) 26: 1267-1277 [PMID:6310112]
ChEMBL Ability to inhibit Angiotensin I converting enzyme was determined B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1984) 27: 816-818 [PMID:6330355]
ChEMBL Compound was tested for its inhibitory activity against Angiotensin I converting enzyme B 7.89 pIC50 13 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 2123-2128 [PMID:9873498]
ChEMBL Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme B 8 pIC50 10 nM IC50 J. Med. Chem. (1995) 38: 5023-5030 [PMID:8544178]
ChEMBL In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base B 8.44 pIC50 3.6 nM IC50 Bioorg. Med. Chem. Lett. (1991) 1: 581-584
ChEMBL In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base. (reported from ref. 1b) B 8.64 pIC50 2.3 nM IC50 Bioorg. Med. Chem. Lett. (1991) 1: 581-584
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820]
ChEMBL Inhibition of Angiotensin I converting enzyme (ACE) B 8.7 pKi 2 nM Ki J. Med. Chem. (2002) 45: 1477-1486 [PMID:11906289]
ChEMBL Inhibitory activity against Angiotensin I converting enzyme B 6.23 pIC50 590 nM IC50 J. Med. Chem. (1986) 29: 411-417 [PMID:3005576]
ChEMBL In vitro antihypertensive activity determined by inhibition of angiotensin I converting enzyme B 6.81 pIC50 156 nM IC50 J. Med. Chem. (1983) 26: 381-394 [PMID:6298428]
ChEMBL Inhibition of Angiotensin I converting enzyme in rat B 7.15 pIC50 70 nM IC50 J. Med. Chem. (1985) 28: 1517-1521 [PMID:2995670]
ChEMBL In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive rats B 7.64 pIC50 23 nM IC50 J. Med. Chem. (1985) 28: 1067-1071 [PMID:2991518]
ChEMBL In vitro inhibitory activity against angiotensin I converting enzyme of rats. B 7.64 pIC50 23 nM IC50 J. Med. Chem. (1988) 31: 1148-1160 [PMID:2836590]
ChEMBL Inhibition of Angiotensin I converting enzyme in rat B 7.82 pIC50 15 nM IC50 J. Med. Chem. (1985) 28: 1517-1521 [PMID:2995670]
ChEMBL Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. B 7.92 pIC50 12 nM IC50 J. Med. Chem. (1987) 30: 992-998 [PMID:3035180]
ChEMBL In vitro inhibitory activity against Angiotensin I converting enzyme B 7.96 pIC50 11 nM IC50 J. Med. Chem. (1983) 26: 394-403 [PMID:6298429]
ChEMBL Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assay B 8.49 pIC50 3.23 nM IC50 Eur J Med Chem (2017) 139: 401-411 [PMID:28810191]
ChEMBL In vitro inhibitory activity against rat serum angiotensin I converting enzyme using hippuryl-glycyl-glycine as substrate B 8.52 pIC50 3 nM IC50 J. Med. Chem. (1993) 36: 699-707 [PMID:8459398]
Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293244] [UniProtKB: Q79MP6]
ChEMBL Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis B 5.62 pKi 2400 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 6229-6232 [PMID:22921080]
ChEMBL Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis B 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6229-6232 [PMID:22921080]
Beta-lactamase II in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079847] [UniProtKB: Q93T40]
ChEMBL Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis B 4.75 pKi 17900 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 6229-6232 [PMID:22921080]
ChEMBL Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis B 4.59 pIC50 25800 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 6229-6232 [PMID:22921080]
Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422]
ChEMBL Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay B 4.85 pKd 14125.38 nM Kd Bioorg. Med. Chem. Lett. (2016) 26: 1973-1977 [PMID:26976213]
ChEMBL Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay B 4.85 pKd 14000 nM Kd Bioorg. Med. Chem. Lett. (2016) 26: 1973-1977 [PMID:26976213]
ChEMBL Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate B 4.3 pIC50 50118.72 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1973-1977 [PMID:26976213]
ChEMBL Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate B 4.3 pIC50 49800 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 1973-1977 [PMID:26976213]
Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0]
ChEMBL Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis B 6.22 pKd 600 nM Kd J. Med. Chem. (2015) 58: 8671-8682 [PMID:26477515]
ChEMBL Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate preincubated for 5 mins followed by substrate addition measured every 17 secs for 20 mins by microplate reader analysis B 5.46 pIC50 3500 nM IC50 J. Med. Chem. (2015) 58: 8671-8682 [PMID:26477515]
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219]
ChEMBL Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method B 4.77 pKi 17000 nM Ki J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354]
ChEMBL Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method B 4.92 pKi 12000 nM Ki J. Med. Chem. (2013) 56: 8377-8388 [PMID:24088053]
Endothelin-converting enzyme 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4791] [GtoPdb: 1615] [UniProtKB: P42892]
ChEMBL Inhibition of Endothelin-converting enzyme 1 (ECE) B 5 pKi >10000 nM Ki J. Med. Chem. (2002) 45: 1477-1486 [PMID:11906289]
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method B 5.07 pKd 8470 nM Kd Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294]
ChEMBL Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method B 5.2 pKd 6370 nM Kd Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294]
ChEMBL Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method B 5.2 pKd 6250 nM Kd Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294]
ChEMBL Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay B 5.43 pKi 3700 nM Ki Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294]
ChEMBL Inhibition of human recombinant leukotriene A4 hydrolase B 4.85 pIC50 14000 nM IC50 Bioorg. Med. Chem. Lett. (2008) 18: 4529-4532 [PMID:18674901]
ChEMBL Inhibitory activity against recombinant human Leukotriene A4 hydrolase B 5 pIC50 10000 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 2517-2522
ChEMBL Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay B 5.44 pIC50 3600 nM IC50 Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294]
ChEMBL Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes B 7.15 pIC50 70 nM IC50 Bioorg. Med. Chem. Lett. (1991) 1: 551-556
Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049]
ChEMBL Inhibition of neutral endopeptidase (NEP) B 6 pKi >1000 nM Ki J. Med. Chem. (2002) 45: 1477-1486 [PMID:11906289]
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797]
ChEMBL Antihypertensive activity against human renin B 8.77 pKi 1.7 nM Ki J. Med. Chem. (1981) 24: 355-361 [PMID:6267277]
Succinyl-diaminopimelate desuccinylase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075192] [UniProtKB: P44514]
ChEMBL Inhibition of Haemophilus influenzae recombinant DapE by competitive binding assay B 5.74 pKi 1820 nM Ki Bioorg. Med. Chem. Lett. (2009) 19: 6350-6352 [PMID:19822427]
ChEMBL Inhibition of Haemophilus influenzae recombinant DapE B 5.48 pIC50 3300 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 6350-6352 [PMID:19822427]
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734]
ChEMBL Inhibitory activity against thrombin B 7.32 pKi 48 nM Ki Bioorg. Med. Chem. Lett. (2004) 14: 3727-3731 [PMID:15203151]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]