Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL1560 (Acepril, Apopril, C09AA01, Capoten, Captomax, Captomex, Captopril, Captoprilum, Ecopace, Farcopril, Garranil, Hypopress, Hyteneze 12.5, Hyteneze 25, Hyteneze 50, Kaplon, Lopril, Mepha, Noyada, NSC-757419, SA-333, SQ -14225, SQ 14,225, SQ-14225, Tensiomin, Tensobon, Zapto) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
GtoPdb | - | - | 8.4 | pKi | 3.98 | nM | Ki | Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274] |
ChEMBL | Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1985) 28: 1291-1295 [PMID:2993618] |
ChEMBL | Inhibition of angiotensin converting enzyme (unknown origin) | B | 6.38 | pIC50 | 420 | nM | IC50 | Eur J Med Chem (2021) 226: 113877-113877 [PMID:34624823] |
ChEMBL | Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzyme | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1980) 23: 1392-1398 [PMID:6256550] |
ChEMBL | Compound was evaluated for inhibition of porcine plasma Angiotensin I converting enzyme by using fluorometric assay | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1985) 28: 1062-1066 [PMID:2991517] |
ChEMBL | Inhibition of ACE (unknown origin) | B | 6.68 | pIC50 | 208.93 | nM | IC50 | Bioorg Med Chem Lett (2022) 75: 128983-128983 [PMID:36096342] |
ChEMBL | Inhibition of angiotensin I converting enzyme in silico | B | 7.1 | pIC50 | 79.43 | nM | IC50 | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
ChEMBL | Inhibition of ACE (unknown origin) | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (2022) 75: 128983-128983 [PMID:36096342] |
ChEMBL | Compound was tested for inhibitory activity against Angiotensin I converting enzyme | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1953-1958 |
ChEMBL | Inhibition of ACE (unknown origin) using hippuryl-L-histidyl-L-leucine as substrate preincubated with substrate for 30 mins followed by enzyme addition measured after 30 mins by LC/MS analysis | B | 7.6 | pIC50 | 25 | nM | IC50 | J Nat Prod (2018) 81: 349-355 [PMID:29405714] |
ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in Hog plasma | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
ChEMBL | Inhibitory concentration against angiotensin I converting enzyme | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
ChEMBL | In vitro inhibition against angiotensin converting enzyme (ACE) | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2673-2676 |
ChEMBL | Inhibition of ACE | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4529-4532 [PMID:18674901] |
ChEMBL | Inhibition of angiotensin-converting enzyme (unknown origin) | B | 7.64 | pIC50 | 22.91 | nM | IC50 | Medchemcomm (2012) 3: 1290-1293 |
ChEMBL | Inhibitory activity against angiotensin converting enzyme (ACE) | F | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (1993) 36: 2390-2403 [PMID:8360884] |
ChEMBL | Inhibition of human recombinant ACE/CD143 somatic form using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins prior to substrate addition measured for 30 mins by spectrophotometric analysis | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 7997-8007 [PMID:24074025] |
ChEMBL | Inhibition of Angiotensin I converting enzyme | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1985) 28: 393-399 [PMID:2983076] |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1985) 28: 434-442 [PMID:2984419] |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
ChEMBL | Inhibition of guinea pig angiotensin I converting enzyme | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1986) 29: 1953-1961 [PMID:3020249] |
ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 7.89 | pIC50 | 12.9 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
ChEMBL | Inhibition of angiotensin-converting enzyme (unknown origin) | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (2016) 59: 10865-10890 [PMID:27690430] |
ChEMBL | Concentration required for 50% inhibition of Angiotensin I converting enzyme | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1981) 24: 104-109 [PMID:6259352] |
ChEMBL | Inhibition of human ACE-mediated amyloid beta hydrolysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2014) 79: 184-193 [PMID:24735644] |
ChEMBL | In vitro inhibitory concentration against angiotensin-converting enzyme | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2715-2720 |
ChEMBL | Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50% | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (1981) 24: 964-969 [PMID:6173481] |
ChEMBL | Inhibition of ACE (unknown origin) using tripeptide Hip-His-Leu-OH as substrate incubated for 4 mins by fluorimetric method | B | 8.2 | pIC50 | 6.3 | nM | IC50 | Bioorg Med Chem Lett (2022) 75: 128983-128983 [PMID:36096342] |
ChEMBL | Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric method | B | 8.2 | pIC50 | 6.3 | nM | IC50 | J Med Chem (2018) 61: 3779-3798 [PMID:29039662] |
ChEMBL | Inhibition of ACE by fluorometric assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Nat Prod (1988) 51: 357-359 [PMID:3379417] |
ChEMBL | Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated for 1 hr by colorimetric assay | B | 8.79 | pIC50 | 1.61 | nM | IC50 | J Nat Prod (2015) 78: 1179-1183 [PMID:25922884] |
ChEMBL | Inhibition of human ACE | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
ChEMBL | Inhibition of human recombinant ACE by fluorimetry | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4715-4719 [PMID:19596577] |
ChEMBL | Inhibition of human ACE C domain | B | 4.67 | pEC50 | 21208.01 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5084-5087 [PMID:16889963] |
ChEMBL | Inhibition of human ACE K1087A mutant | B | 4.73 | pEC50 | 18539.58 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5084-5087 [PMID:16889963] |
Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
ChEMBL | Inhibitory activity against rabbit lung angiotensin-1 converting enzyme | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 6.89 | pIC50 | 130 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
ChEMBL | In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrate | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1783-1788 |
ChEMBL | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1988) 31: 204-212 [PMID:3336020] |
ChEMBL | Ability to inhibit Angiotensin I converting enzyme was determined | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1984) 27: 816-818 [PMID:6330355] |
ChEMBL | In vitro 50% inhibition of Angiotensin I converting enzyme | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (1988) 31: 875-885 [PMID:2832605] |
ChEMBL | Inhibitory concentration against angiotensin converting enzyme (ACE) | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2799-2804 |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme in rabbit lung, using hippuryl-histidyl-leucine as substrate | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1982) 25: 250-258 [PMID:6279843] |
ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in rabbit lung | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
ChEMBL | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1986) 29: 784-796 [PMID:3009814] |
ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
ChEMBL | Ability to inhibit Angiotensin I converting enzyme was determined | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1984) 27: 816-818 [PMID:6330355] |
ChEMBL | In vitro inhibition of Angiotensin I converting enzyme | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1983) 26: 1267-1277 [PMID:6310112] |
ChEMBL | In vitro inhibition of angiotensin I converting enzyme (ACE) | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1983) 26: 1277-1282 [PMID:6310113] |
ChEMBL | Compound was tested for its inhibitory activity against Angiotensin I converting enzyme | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2123-2128 [PMID:9873498] |
ChEMBL | Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1995) 38: 5023-5030 [PMID:8544178] |
ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base. (reported from ref. 1b) | B | 8.64 | pIC50 | 2.3 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 13.57 | pIC50 | 0 | nM | IC50 | J Med Chem (1985) 28: 328-332 [PMID:2983075] |
Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
ChEMBL | Inhibitory activity against Angiotensin I converting enzyme | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (1986) 29: 411-417 [PMID:3005576] |
ChEMBL | In vitro antihypertensive activity determined by inhibition of angiotensin I converting enzyme | B | 6.81 | pIC50 | 156 | nM | IC50 | J Med Chem (1983) 26: 381-394 [PMID:6298428] |
ChEMBL | Inhibition of Angiotensin I converting enzyme in rat | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (1985) 28: 1517-1521 [PMID:2995670] |
ChEMBL | In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive rats | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1985) 28: 1067-1071 [PMID:2991518] |
ChEMBL | In vitro inhibitory activity against angiotensin I converting enzyme of rats. | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
ChEMBL | Inhibition of Angiotensin I converting enzyme in rat | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1985) 28: 1517-1521 [PMID:2995670] |
ChEMBL | Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1987) 30: 992-998 [PMID:3035180] |
ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1983) 26: 394-403 [PMID:6298429] |
ChEMBL | Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assay | B | 8.49 | pIC50 | 3.23 | nM | IC50 | Eur J Med Chem (2017) 139: 401-411 [PMID:28810191] |
ChEMBL | In vitro inhibitory activity against rat serum angiotensin I converting enzyme using hippuryl-glycyl-glycine as substrate | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1993) 36: 699-707 [PMID:8459398] |
Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293244] [UniProtKB: Q79MP6] | ||||||||
ChEMBL | Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 5.62 | pKi | 2400 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
ChEMBL | Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
Beta-lactamase II in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079847] [UniProtKB: Q93T40] | ||||||||
ChEMBL | Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 4.75 | pKi | 17900 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
ChEMBL | Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422] | ||||||||
ChEMBL | Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay | B | 4.85 | pKd | 14125.38 | nM | Kd | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
ChEMBL | Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay | B | 4.85 | pKd | 14000 | nM | Kd | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
ChEMBL | Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate | B | 4.3 | pIC50 | 50118.72 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
ChEMBL | Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate | B | 4.3 | pIC50 | 49800 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0] | ||||||||
ChEMBL | Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis | B | 6.22 | pKd | 600 | nM | Kd | J Med Chem (2015) 58: 8671-8682 [PMID:26477515] |
ChEMBL | Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate preincubated for 5 mins followed by substrate addition measured every 17 secs for 20 mins by microplate reader analysis | B | 5.46 | pIC50 | 3500 | nM | IC50 | J Med Chem (2015) 58: 8671-8682 [PMID:26477515] |
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
ChEMBL | Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.77 | pKi | 17000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
Endothelin-converting enzyme 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4791] [GtoPdb: 1615] [UniProtKB: P42892] | ||||||||
ChEMBL | Inhibition of Endothelin-converting enzyme 1 (ECE) | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method | B | 5.07 | pKd | 8470 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method | B | 5.2 | pKd | 6370 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method | B | 5.2 | pKd | 6250 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
ChEMBL | Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay | B | 5.43 | pKi | 3700 | nM | Ki | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
ChEMBL | Inhibition of human recombinant leukotriene A4 hydrolase | B | 4.85 | pIC50 | 14000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4529-4532 [PMID:18674901] |
ChEMBL | Inhibitory activity against recombinant human Leukotriene A4 hydrolase | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2517-2522 |
ChEMBL | Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay | B | 5.44 | pIC50 | 3600 | nM | IC50 | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
ChEMBL | Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 551-556 |
Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049] | ||||||||
ChEMBL | Inhibition of neutral endopeptidase (NEP) | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
ChEMBL | Antihypertensive activity against human renin | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (1981) 24: 355-361 [PMID:6267277] |
Succinyl-diaminopimelate desuccinylase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075192] [UniProtKB: P44514] | ||||||||
ChEMBL | Inhibition of Haemophilus influenzae recombinant DapE by competitive binding assay | B | 5.74 | pKi | 1820 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6350-6352 [PMID:19822427] |
ChEMBL | Inhibition of Haemophilus influenzae recombinant DapE | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6350-6352 [PMID:19822427] |
coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
ChEMBL | Inhibitory activity against thrombin | B | 7.32 | pKi | 48 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3727-3731 [PMID:15203151] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]