captopril [Ligand Id: 5158] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1560 (Acepril, Apopril, C09AA01, Capoten, Captomax, Captomex, Captopril, Captoprilum, Ecopace, Farcopril, Garranil, Hypopress, Hyteneze 12.5, Hyteneze 25, Hyteneze 50, Kaplon, Lopril, Mepha, Noyada, NSC-757419, SA-333, SQ -14225, SQ 14,225, SQ-14225, Tensiomin, Tensobon, Zapto) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | 3.98 | nM | Ki | Mol Pharmacol (1997) 51: 1070-6 [PMID:9187274] |
| ChEMBL | Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme from unpurified guinea pig serum | B | 5.89 | pIC50 | 1300 | nM | IC50 | J Med Chem (1985) 28: 1291-1295 [PMID:2993618] |
| ChEMBL | Compound is evaluated for the inhibition of porcine plasma Angiotensin I converting enzyme | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1980) 23: 1392-1398 [PMID:6256550] |
| ChEMBL | Compound was evaluated for inhibition of porcine plasma Angiotensin I converting enzyme by using fluorometric assay | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1985) 28: 1062-1066 [PMID:2991517] |
| ChEMBL | Inhibition of angiotensin I converting enzyme in silico | B | 7.1 | pIC50 | 79.43 | nM | IC50 | J Med Chem (1997) 40: 3161-3172 [PMID:9379435] |
| ChEMBL | Compound was tested for inhibitory activity against Angiotensin I converting enzyme | B | 7.52 | pIC50 | 30 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 1953-1958 |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in Hog plasma | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | Inhibition of ACE (unknown origin) using hippuryl-L-histidyl-L-leucine as substrate preincubated with substrate for 30 mins followed by enzyme addition measured after 30 mins by LC/MS analysis | B | 7.6 | pIC50 | 25 | nM | IC50 | J Nat Prod (2018) 81: 349-355 [PMID:29405714] |
| ChEMBL | Inhibition of ACE | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4529-4532 [PMID:18674901] |
| ChEMBL | In vitro inhibition against angiotensin converting enzyme (ACE) | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2673-2676 |
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| ChEMBL | Inhibitory concentration against angiotensin I converting enzyme | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (2005) 48: 6523-6543 [PMID:16220969] |
| ChEMBL | Inhibitory activity against angiotensin converting enzyme (ACE) | F | 7.64 | pIC50 | 22.91 | nM | IC50 | J Med Chem (1993) 36: 2390-2403 [PMID:8360884] |
| ChEMBL | Inhibition of angiotensin-converting enzyme (unknown origin) | B | 7.64 | pIC50 | 22.91 | nM | IC50 | Medchemcomm (2012) 3: 1290-1293 |
| ChEMBL | Inhibition of human recombinant ACE/CD143 somatic form using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2.AcOH as substrate preincubated for 10 mins prior to substrate addition measured for 30 mins by spectrophotometric analysis | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (2013) 56: 7997-8007 [PMID:24074025] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1985) 28: 434-442 [PMID:2984419] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1985) 28: 393-399 [PMID:2983076] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
| ChEMBL | Inhibition of guinea pig angiotensin I converting enzyme | B | 7.89 | pIC50 | 13 | nM | IC50 | J Med Chem (1986) 29: 1953-1961 [PMID:3020249] |
| ChEMBL | Compound tested in vitro for inhibition of Angiotensin I converting enzyme | B | 7.89 | pIC50 | 12.9 | nM | IC50 | J Med Chem (1989) 32: 1600-1606 [PMID:2544729] |
| ChEMBL | Concentration required for 50% inhibition of Angiotensin I converting enzyme | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1981) 24: 104-109 [PMID:6259352] |
| ChEMBL | Inhibition of human ACE-mediated amyloid beta hydrolysis | B | 7.96 | pIC50 | 11 | nM | IC50 | Eur J Med Chem (2014) 79: 184-193 [PMID:24735644] |
| ChEMBL | In vitro inhibitory concentration against angiotensin-converting enzyme | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2715-2720 |
| ChEMBL | Concentration required to inhibit the activity of Angiotensin I converting enzyme by 50% | B | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (1981) 24: 964-969 [PMID:6173481] |
| ChEMBL | Inhibition of human ACE using Hip-His-Leu-OH as substrate after 1 hr by fluorimetric method | B | 8.2 | pIC50 | 6.3 | nM | IC50 | J Med Chem (2018) 61: 3779-3798 [PMID:29039662] |
| ChEMBL | Inhibition of ACE by fluorometric assay | B | 8.3 | pIC50 | 5 | nM | IC50 | J Nat Prod (1988) 51: 357-359 [PMID:3379417] |
| ChEMBL | Inhibition of ACE (unknown origin) using 3-Hydroxybutylyl-Gly-Gly-Gly substrate assessed as reduction in 3-Hyroxybutylic acid generation incubated for 1 hr by colorimetric assay | B | 8.79 | pIC50 | 1.61 | nM | IC50 | J Nat Prod (2015) 78: 1179-1183 [PMID:25922884] |
| ChEMBL | Inhibition of human ACE | B | 9.2 | pIC50 | 0.63 | nM | IC50 | J Med Chem (2008) 51: 4150-4169 [PMID:18588282] |
| ChEMBL | Inhibition of human recombinant ACE by fluorimetry | B | 9.92 | pIC50 | 0.12 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4715-4719 [PMID:19596577] |
| ChEMBL | Inhibition of human ACE C domain | B | 4.67 | pEC50 | 21208.01 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5084-5087 [PMID:16889963] |
| ChEMBL | Inhibition of human ACE K1087A mutant | B | 4.73 | pEC50 | 18539.58 | nM | EC50 | Bioorg Med Chem Lett (2006) 16: 5084-5087 [PMID:16889963] |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibitory activity against rabbit lung angiotensin-1 converting enzyme | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
| ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base | B | 5.62 | pIC50 | 2400 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
| ChEMBL | DRUGMATRIX: Peptidase, Angiotensin Converting Enzyme enzyme inhibition (substrate: FAPGG) | B | 6.89 | pIC50 | 130 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme | B | 7.57 | pIC50 | 27 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
| ChEMBL | In vitro inhibition of rabbit lung Angiotensin I converting enzyme (ACE) using Hippuryl-His-Leu as substrate | B | 7.64 | pIC50 | 23 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 1783-1788 |
| ChEMBL | In vitro inhibition of angiotensin I converting enzyme in rabbit lung with hippuryl-histidyl-leucine as substrate | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1988) 31: 204-212 [PMID:3336020] |
| ChEMBL | Ability to inhibit Angiotensin I converting enzyme was determined | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1984) 27: 816-818 [PMID:6330355] |
| ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
| ChEMBL | In vitro 50% inhibition of Angiotensin I converting enzyme | B | 7.66 | pIC50 | 22 | nM | IC50 | J Med Chem (1988) 31: 875-885 [PMID:2832605] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme in rabbit lung, using hippuryl-histidyl-leucine as substrate | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1982) 25: 250-258 [PMID:6279843] |
| ChEMBL | Inhibitory concentration against angiotensin converting enzyme (ACE) | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 2799-2804 |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme in rabbit lung | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1990) 33: 1606-1615 [PMID:2160536] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme activity at pH 8.5 in rabbit lung | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1986) 29: 784-796 [PMID:3009814] |
| ChEMBL | In vitro inhibitory activity against rabbit lung Angiotensin I converting enzyme at pH 8.3 | B | 7.77 | pIC50 | 17 | nM | IC50 | J Med Chem (1985) 28: 57-66 [PMID:2981324] |
| ChEMBL | In vitro inhibition of angiotensin I converting enzyme (ACE) | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1983) 26: 1277-1282 [PMID:6310113] |
| ChEMBL | In vitro inhibition of Angiotensin I converting enzyme | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1983) 26: 1267-1277 [PMID:6310112] |
| ChEMBL | Ability to inhibit Angiotensin I converting enzyme was determined | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1984) 27: 816-818 [PMID:6330355] |
| ChEMBL | Compound was tested for its inhibitory activity against Angiotensin I converting enzyme | B | 7.89 | pIC50 | 13 | nM | IC50 | Bioorg Med Chem Lett (1998) 8: 2123-2128 [PMID:9873498] |
| ChEMBL | Evaluation of in vitro inhibitory activity against Angiotensin I converting enzyme | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1995) 38: 5023-5030 [PMID:8544178] |
| ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base | B | 8.44 | pIC50 | 3.6 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
| ChEMBL | In vitro inhibitory activity was evaluated against angiotensin converting enzyme from rabbit in bovine buffered base. (reported from ref. 1b) | B | 8.64 | pIC50 | 2.3 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 581-584 |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | Inhibition of Angiotensin I converting enzyme (ACE) | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
| ChEMBL | Inhibitory activity against Angiotensin I converting enzyme | B | 6.23 | pIC50 | 590 | nM | IC50 | J Med Chem (1986) 29: 411-417 [PMID:3005576] |
| ChEMBL | In vitro antihypertensive activity determined by inhibition of angiotensin I converting enzyme | B | 6.81 | pIC50 | 156 | nM | IC50 | J Med Chem (1983) 26: 381-394 [PMID:6298428] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme in rat | B | 7.15 | pIC50 | 70 | nM | IC50 | J Med Chem (1985) 28: 1517-1521 [PMID:2995670] |
| ChEMBL | In vivo inhibitory activity against Angiotensin I converting enzyme was evaluated in renal hypertensive rats | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1985) 28: 1067-1071 [PMID:2991518] |
| ChEMBL | In vitro inhibitory activity against angiotensin I converting enzyme of rats. | B | 7.64 | pIC50 | 23 | nM | IC50 | J Med Chem (1988) 31: 1148-1160 [PMID:2836590] |
| ChEMBL | Inhibition of Angiotensin I converting enzyme in rat | B | 7.82 | pIC50 | 15 | nM | IC50 | J Med Chem (1985) 28: 1517-1521 [PMID:2995670] |
| ChEMBL | Inhibition of rat Angiotensin I converting enzyme (ACE), using Hip-Gly-Gly as synthetic substrate. | B | 7.92 | pIC50 | 12 | nM | IC50 | J Med Chem (1987) 30: 992-998 [PMID:3035180] |
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 7.96 | pIC50 | 11 | nM | IC50 | J Med Chem (1983) 26: 394-403 [PMID:6298429] |
| ChEMBL | Inhibition of Wistar rat plasma angiotensin 1-converting enzyme using H-hippuryl-His-Leu-OH as substrate after 20 mins by fluorescence assay | B | 8.49 | pIC50 | 3.23 | nM | IC50 | Eur J Med Chem (2017) 139: 401-411 [PMID:28810191] |
| ChEMBL | In vitro inhibitory activity against rat serum angiotensin I converting enzyme using hippuryl-glycyl-glycine as substrate | B | 8.52 | pIC50 | 3 | nM | IC50 | J Med Chem (1993) 36: 699-707 [PMID:8459398] |
| Beta-lactamase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1293244] [UniProtKB: Q79MP6] | ||||||||
| ChEMBL | Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 5.62 | pKi | 2400 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
| ChEMBL | Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
| Beta-lactamase II in Bacillus anthracis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2079847] [UniProtKB: Q93T40] | ||||||||
| ChEMBL | Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 4.75 | pKi | 17900 | nM | Ki | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
| ChEMBL | Inhibition of Bacillus anthracis MBL Bla2 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis | B | 4.59 | pIC50 | 25800 | nM | IC50 | Bioorg Med Chem Lett (2012) 22: 6229-6232 [PMID:22921080] |
| Beta-lactamase NDM-1 in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1667695] [UniProtKB: C7C422] | ||||||||
| ChEMBL | Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay | B | 4.85 | pKd | 14125.38 | nM | Kd | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
| ChEMBL | Binding affinity to His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells by surface plasmon resonance assay | B | 4.85 | pKd | 14000 | nM | Kd | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
| ChEMBL | Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate | B | 4.3 | pIC50 | 50118.72 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
| ChEMBL | Inhibition of His-tagged Klebsiella pneumoniae NDM-1 expressed in Escherichia coli BL21-AI cells using imipinem as substrate | B | 4.3 | pIC50 | 49800 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1973-1977 [PMID:26976213] |
| Beta-lactamase VIM-2 in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5798] [UniProtKB: Q9K2N0] | ||||||||
| ChEMBL | Reversible binding affinity to Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) measured for 15 secs by SPR analysis | B | 6.22 | pKd | 600 | nM | Kd | J Med Chem (2015) 58: 8671-8682 [PMID:26477515] |
| ChEMBL | Inhibition of Pseudomonas aeruginosa 301-5473 metallo-beta-lactamase VIM-2 expressed in Escherichia coli BL21(DE3) using nitrocefin as substrate preincubated for 5 mins followed by substrate addition measured every 17 secs for 20 mins by microplate reader analysis | B | 5.46 | pIC50 | 3500 | nM | IC50 | J Med Chem (2015) 58: 8671-8682 [PMID:26477515] |
| COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
| ChEMBL | Inhibition of COX-1 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.77 | pKi | 17000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
| COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
| ChEMBL | Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate assessed as formation of prostanoid products preincubated for 10 mins prior to substrate addition measured after 2 mins by Ellman's method | B | 4.92 | pKi | 12000 | nM | Ki | J Med Chem (2013) 56: 8377-8388 [PMID:24088053] |
| Endothelin-converting enzyme 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4791] [GtoPdb: 1615] [UniProtKB: P42892] | ||||||||
| ChEMBL | Inhibition of Endothelin-converting enzyme 1 (ECE) | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
| Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] | ||||||||
| ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 35 degC by ITC method | B | 5.07 | pKd | 8470 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
| ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 15 degC by ITC method | B | 5.2 | pKd | 6370 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
| ChEMBL | Binding affinity to human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H at 25 degC by ITC method | B | 5.2 | pKd | 6250 | nM | Kd | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
| ChEMBL | Competitive inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using varying levels of L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay | B | 5.43 | pKi | 3700 | nM | Ki | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
| ChEMBL | Inhibition of human recombinant leukotriene A4 hydrolase | B | 4.85 | pIC50 | 14000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4529-4532 [PMID:18674901] |
| ChEMBL | Inhibitory activity against recombinant human Leukotriene A4 hydrolase | B | 5 | pIC50 | 10000 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 2517-2522 |
| ChEMBL | Inhibition of human C-terminal his6-tagged/N-terminal T7 gene leader sequence-tagged LTA4H using L-arginine-7-amino-4-Methylcoumarine as substrate preincubated for 30 mins followed by substrate addition measured for 30 mins by fluorescence assay | B | 5.44 | pIC50 | 3600 | nM | IC50 | Bioorg Med Chem (2016) 24: 5243-5248 [PMID:27651294] |
| ChEMBL | Inhibitory activity against Leukotriene A4 hydrolase from human leukocytes | B | 7.15 | pIC50 | 70 | nM | IC50 | Bioorg Med Chem Lett (1991) 1: 551-556 |
| Neprilysin in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3768] [UniProtKB: P08049] | ||||||||
| ChEMBL | Inhibition of neutral endopeptidase (NEP) | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (2002) 45: 1477-1486 [PMID:11906289] |
| renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
| ChEMBL | Antihypertensive activity against human renin | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (1981) 24: 355-361 [PMID:6267277] |
| Succinyl-diaminopimelate desuccinylase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075192] [UniProtKB: P44514] | ||||||||
| ChEMBL | Inhibition of Haemophilus influenzae recombinant DapE by competitive binding assay | B | 5.74 | pKi | 1820 | nM | Ki | Bioorg Med Chem Lett (2009) 19: 6350-6352 [PMID:19822427] |
| ChEMBL | Inhibition of Haemophilus influenzae recombinant DapE | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 6350-6352 [PMID:19822427] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Inhibitory activity against thrombin | B | 7.32 | pKi | 48 | nM | Ki | Bioorg Med Chem Lett (2004) 14: 3727-3731 [PMID:15203151] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
