apraglutide   Click here for help

GtoPdb Ligand ID: 10685

Synonyms: CVQ1IAY2G6 | FE 203799 | FE203799
Comment: Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, with amino acid substitutions (Ala2>Gly, Met10>Ahx, Asn11>D-Phe, Asn16>Leu). The peptide's circulating half-life is elevated by the incorporation of Ahx (aminocaproic acid) in place of lysine which reduces degradation by lysine-targeting proteolytic enzymes. Apraglutide enhances adaptation and linear intestinal growth in a neonatal piglet model with total resection of the ileum that mimics human short bowel syndrome [2].
Click here for help
Classification Click here for help
Compound class Peptide or derivative
International Nonproprietary Names Click here for help
INN number INN
10705 apraglutide
Synonyms Click here for help
CVQ1IAY2G6 | FE 203799 | FE203799
Database Links Click here for help
Specialist databases
GPCRdb Ligand apraglutide
Other databases
CAS Registry No. 1295353-98-8
GtoPdb PubChem SID 404859132
PubChem SID 381126894
Search PubMed clinical trials apraglutide
Search PubMed titles apraglutide
Search PubMed titles/abstracts apraglutide