apraglutide   Click here for help

GtoPdb Ligand ID: 10685

Synonyms: CVQ1IAY2G6 | FE 203799 | FE203799
Comment: Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, with amino acid substitutions (Ala2>Gly, Met10>Ahx, Asn11>D-Phe, Asn16>Leu). The peptide's circulating half-life is elevated by the incorporation of Ahx (aminocaproic acid) in place of lysine which reduces degradation by lysine-targeting proteolytic enzymes. Apraglutide enhances adaptation and linear intestinal growth in a neonatal piglet model with total resection of the ileum that mimics human short bowel syndrome [2].
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GLP-2 receptor Hs Agonist Agonist 10.5 pEC50 - 1-2
pEC50 10.5 (EC50 3x10-11 M) [1-2]