apraglutide   Click here for help

GtoPdb Ligand ID: 10685

Synonyms: CVQ1IAY2G6 | FE 203799 | FE203799
Comment: Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, with amino acid substitutions (Ala2>Gly, Met10>Ahx, Asn11>D-Phe, Asn16>Leu). The peptide's circulating half-life is elevated by the incorporation of Ahx (aminocaproic acid) in place of lysine which reduces degradation by lysine-targeting proteolytic enzymes. Apraglutide enhances adaptation and linear intestinal growth in a neonatal piglet model with total resection of the ileum that mimics human short bowel syndrome [2].
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Summary of Clinical Use Click here for help
FE 203799 is being investigated as a therapeutic option for short bowel syndrome [1].
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT03408132 Metabolic Balance Study of FE203799 in Patients With SBS With Intestinal Insufficiency Phase 1/Phase 2 Interventional GLyPharma Therapeutic