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ChEMBL ligand: CHEMBL2407634 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413] | ||||||||
ChEMBL | Competitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using ATP as substrate after 30 mins by capillary electrophoresis method | B | 4.84 | pKi | 14600 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
ChEMBL | Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by capillary electrophoresis method | B | 5.53 | pKi | 2960 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3] | ||||||||
ChEMBL | Competitive-inhibition of Wistar rat NPP1 using p-Nph-5'-TMP as substrate measured after 5 mins by UPLC method | B | 4.69 | pKi | 20500 | nM | Ki | Medchemcomm (2017) 8: 823-840 [PMID:30108800] |
P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91] | ||||||||
GtoPdb | - | - | 5.1 | pEC50 | - | - | - | Br J Pharmacol (1999) 128: 1199-206 [PMID:10578132] |
P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572] | ||||||||
GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 5.33 | pEC50 | 4677 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
P2X7 in Mouse [GtoPdb: 484] [UniProtKB: Q9Z1M0] | ||||||||
GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 4 | pEC50 | 100000 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
P2X7 in Rat [GtoPdb: 484] [UniProtKB: Q64663] | ||||||||
GtoPdb | Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. | - | 5 | pEC50 | 10000 | nM | EC50 | Br J Pharmacol (2009) 157: 1203-14 [PMID:19558545] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]