BzATP [Ligand Id: 1757] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2407634
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
  • Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3]
1 CHEMBL2407634_lig_chart_1 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 HumanRat
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  • P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91]
  • This target only has 0 pki data point
2 CHEMBL2407634_lig_chart_2 P2Y11 receptor Human
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  • P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572]
  • P2X7 in Mouse [GtoPdb: 484] [UniProtKB: Q9Z1M0]
  • P2X7 in Rat [GtoPdb: 484] [UniProtKB: Q64663]
  • This target only has 0 pki data point
3 CHEMBL2407634_lig_chart_3 P2X7 HumanMouseRat
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5925] [UniProtKB: P22413]
ChEMBL Competitive-inhibition of recombinant human N-terminal His-tagged soluble NPP1 (Val191 to Leu591 residues) expressed in mouse NSO cells using ATP as substrate after 30 mins by capillary electrophoresis method B 4.84 pKi 14600 nM Ki MedChemComm (2017) 8: 823-840
ChEMBL Competitive-inhibition of recombinant human NPP1 expressed in HEK293 cell membranes using p-Nph-5'-TMP as substrate pretreated for 10 mins followed by substrate addition and measured after 60 mins by capillary electrophoresis method B 5.53 pKi 2960 nM Ki MedChemComm (2017) 8: 823-840
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295913] [UniProtKB: Q924C3]
ChEMBL Competitive-inhibition of Wistar rat NPP1 using p-Nph-5'-TMP as substrate measured after 5 mins by UPLC method B 4.69 pKi 20500 nM Ki MedChemComm (2017) 8: 823-840
P2Y11 receptor in Human [GtoPdb: 327] [UniProtKB: Q96G91]
GtoPdb - - 5.1 pEC50 - - - Br. J. Pharmacol. (1999) 128: 1199-206 [PMID:10578132]
P2X7 in Human [GtoPdb: 484] [UniProtKB: Q99572]
GtoPdb Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. - 5.33 pEC50 4677 nM EC50 Br. J. Pharmacol. (2009) 157: 1203-14 [PMID:19558545]
P2X7 in Mouse [GtoPdb: 484] [UniProtKB: Q9Z1M0]
GtoPdb Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. - 4 pEC50 100000 nM EC50 Br. J. Pharmacol. (2009) 157: 1203-14 [PMID:19558545]
P2X7 in Rat [GtoPdb: 484] [UniProtKB: Q64663]
GtoPdb Measuring agonist-stimulated P2X7 receptor-mediated changes in intracellular calcium concentration. - 5 pEC50 10000 nM EC50 Br. J. Pharmacol. (2009) 157: 1203-14 [PMID:19558545]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]