ChEMBL ligand: CHEMBL1241028
Endothelin-converting enzyme 1/MUS81-ECE1 in Human [ChEMBL: CHEMBL5465380] [GtoPdb: 1615] [UniProtKB: P42892, Q96NY9] There should be some charts here, you may need to enable JavaScript!
ubiquitin C-terminal hydrolase L1/Ubiquitin carboxyl-terminal hydrolase isozyme L1 in Human [ChEMBL: CHEMBL6159] [GtoPdb: 2426] [UniProtKB: P09936] There should be some charts here, you may need to enable JavaScript!
ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Endothelin-converting enzyme 1/MUS81-ECE1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL5465380] [GtoPdb: 1615] [UniProtKB: P42892, Q96NY9]
ChEMBL	Inhibition of human GST-tagged MUS81-ECE1 expressed in Escherichia coli BL21(DE3)Rosetta2 cells incubated for 15 mins by FRET based assay	B	5.74	pIC50	1840	nM	IC50	Bioorg Med Chem (2023) 90: 117383-117383 [PMID:37352577]
ubiquitin C-terminal hydrolase L1/Ubiquitin carboxyl-terminal hydrolase isozyme L1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6159] [GtoPdb: 2426] [UniProtKB: P09936]
ChEMBL	Inhibition of UCHL1 in human H1299 cells	B	4.12	pIC50	75000	nM	IC50	Nat Chem Biol (2007) 3: 697-705 [PMID:17948018]
ubiquitin C-terminal hydrolase L3/Ubiquitin carboxyl-terminal hydrolase isozyme L3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6195] [GtoPdb: 2427] [UniProtKB: P15374]
GtoPdb	-	-	6.22	pIC50	600	nM	IC50	Nat Chem Biol (2007) 3: 697-705 [PMID:17948018]
ChEMBL	Inhibition of UCHL3 in human H1299 cells	B	6.22	pIC50	600	nM	IC50	Nat Chem Biol (2007) 3: 697-705 [PMID:17948018]
ChEMBL	Inhibition of recombinant human UCHL3 expressed in baculovirus infected Sf9 cells using ubiquitin-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence spectrophotometric assay	B	6.22	pIC50	600	nM	IC50	Eur J Med Chem (2022) 227: 113970-113970 [PMID:34752952]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]