DAPI [Ligand Id: 5498] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL48217
  • Cell division protein ftsZ in Escherichia coli [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Cell division protein ftsZ in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3999] [UniProtKB: P0A9A6]
ChEMBL Binding affinity to Escherichia coli FtsZ by fluorescence anisotrophy B 4.78 pKd 16600 nM Kd Eur J Med Chem (2015) 95: 1-15 [PMID:25791674]
Glandular kallikrein in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3243909] [UniProtKB: P00752]
ChEMBL Competitive reversible inhibition of porcine pancreatic kallikrein using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 180 mins by Michaelis-Menten plot analysis B 5.57 pKi 2700 nM Ki J Med Chem (1978) 21: 613-623 [PMID:671460]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 J Med Chem (2008) 51: 6927-6944 [PMID:18841956]
ChEMBL Antiparasitic activity against Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 Bioorg Med Chem (2011) 19: 2156-2167 [PMID:21421317]
ChEMBL Antiparasitic activity against Plasmodium falciparum K1 F 8.52 pIC50 3 nM IC50 Bioorg Med Chem (2010) 18: 557-566 [PMID:20031421]
Thrombin in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4471] [UniProtKB: P00735]
ChEMBL Competitive reversible inhibition of bovine thrombin using alpha-N-benzoyl-DL-arginine-p-nitroanilide hydrochloride as substrate after 15 to 40 mins by Michaelis-Menten plot analysis B 5.08 pKi 8370 nM Ki J Med Chem (1978) 21: 613-623 [PMID:671460]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]