GDC-0334 [Ligand Id: 12568] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4865238 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
| GtoPdb | - | - | 8.77 | pIC50 | 1.69 | nM | IC50 | J Exp Med (2021) 218: [PMID:33620419] |
| ChEMBL | Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assay | B | 8.8 | pIC50 | 1.6 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1230-1237 [PMID:34413952] |
| TRPA1/Transient receptor potential cation channel subfamily A member 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5160] [GtoPdb: 485] [UniProtKB: Q6RI86] | ||||||||
| ChEMBL | Antagonist activity at rat TRPA1 | B | 8 | pIC50 | 10 | nM | IC50 | ACS Med Chem Lett (2021) 12: 1230-1237 [PMID:34413952] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
