ChEMBL ligand: CHEMBL25438
ETA receptor/Endothelin-1 receptor in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] ETA receptor/Endothelin-1 receptor in Rat [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] There should be some charts here, you may need to enable JavaScript!
ETB receptor/Endothelin receptor type B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530] Endothelin receptor type B in Pig [ChEMBL: CHEMBL3949] [UniProtKB: P35463] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ETA receptor/Endothelin-1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	pA2 value towards endothelin receptor A was determined as functional ETA antagonism	F	7.6	pKd	25.12	nM	Kd	Bioorg Med Chem Lett (1998) 8: 17-22 [PMID:9871621]
GtoPdb	-	-	9.8	pKd	0.15	nM	Kd	J Pharmacol Exp Ther (1997) 280: 1102-8 [PMID:9023329]
ChEMBL	Displacement of [125I]endhothelin-1 from human ETA receptor stably expressed in CHO cells Membrane assessed as inhibition constant at 25 degC incubated for 4 hrs by saturation binding assay	B	9.42	pKi	0.38	nM	Ki	Eur J Pharmacol (1999) 366: 189-201 [PMID:10082200]
ChEMBL	Tested for binding affinity for human Endothelin A receptor by measuring its ability to displace [125I]-ET-1 from chinese hamster ovary cells(CHO)	B	9.77	pKi	0.17	nM	Ki	J Med Chem (1998) 41: 3261-3275 [PMID:9703472]
ChEMBL	Binding affinity to ETA receptor (unknown origin) assessed as inhibition constant	B	9.77	pKi	0.17	nM	Ki	Eur J Pharmacol (1999) 366: 189-201 [PMID:10082200]
ChEMBL	Antagonistic activity against human Endothelin A receptor expressed in LtK	F	9.51	pIC50	0.31	nM	IC50	J Med Chem (1995) 38: 1259-1263 [PMID:7731010]
GtoPdb	-	-	9.2	pA2	-	-	-	Stroke (1999) 30: 638-43 [PMID:10066864]; J Pharmacol Exp Ther (1997) 280: 1102-8 [PMID:9023329]
ETA receptor/Endothelin-1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684]
ChEMBL	In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor	B	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1771-1776 [PMID:9873432]
ETB receptor/Endothelin receptor type B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
ChEMBL	Tested for binding affinity for human Endothelin B receptor by measuring its ability to displace [125I]-ET-3 from chinese hamster ovary cells(CHO)	B	6.86	pKi	139	nM	Ki	J Med Chem (1998) 41: 3261-3275 [PMID:9703472]
ChEMBL	Binding affinity to ETB receptor (unknown origin) assessed as inhibition constant	B	6.86	pKi	139	nM	Ki	Eur J Pharmacol (1999) 366: 189-201 [PMID:10082200]
ChEMBL	Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).	F	6.38	pIC50	417	nM	IC50	J Med Chem (1995) 38: 1259-1263 [PMID:7731010]
Endothelin receptor type B in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3949] [UniProtKB: P35463]
ChEMBL	In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptor	B	6.47	pIC50	340	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1771-1776 [PMID:9873432]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]