eflornithine [Ligand Id: 5176] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL830 (Eflornithine, Ornidyl, Vaniqa) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] | ||||||||
| ChEMBL | Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 20 to 40 mins by fluorescence based assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 5247-5253 [PMID:27720295] |
| Ornithine decarboxylase in Human [GtoPdb: 1276] [UniProtKB: P11926] | ||||||||
| GtoPdb | - | - | 4.89 | pKd | 13000 | nM | Kd | Biochem J (2003) 375: 465-70 [PMID:12859253] |
| Ornithine decarboxylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3511] [GtoPdb: 1276] [UniProtKB: P09057] | ||||||||
| ChEMBL | The apparent dissociation constant for irreversible inhibition of rat liver ornithine decarboxylase (ODC) | B | 4.41 | pKi | 39000 | nM | Ki | J Med Chem (1983) 26: 1551-1556 [PMID:6631913] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
