eflornithine [Ligand Id: 5176] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL830 (Eflornithine, Ornidyl, Vaniqa)
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  • Ornithine decarboxylase in Human [GtoPdb: 1276] [UniProtKB: P11926]
  • Ornithine decarboxylase in Rat [ChEMBL: CHEMBL3511] [GtoPdb: 1276] [UniProtKB: P09057]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1Q7BGE6]
ChEMBL Inhibition of Escherichia coli GroEL/GroES expressed in Escherichia coli DH5alpha/BL21 (DE3) assessed as inhibition of denatured MDH refolding preincubated for 10 mins followed by ATP addition measured after 20 to 40 mins by fluorescence based assay B 4 pIC50 >100000 nM IC50 Bioorg Med Chem Lett (2016) 26: 5247-5253 [PMID:27720295]
Ornithine decarboxylase in Human [GtoPdb: 1276] [UniProtKB: P11926]
GtoPdb - - 4.89 pKd 13000 nM Kd Biochem J (2003) 375: 465-70 [PMID:12859253]
Ornithine decarboxylase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3511] [GtoPdb: 1276] [UniProtKB: P09057]
ChEMBL The apparent dissociation constant for irreversible inhibition of rat liver ornithine decarboxylase (ODC) B 4.41 pKi 39000 nM Ki J Med Chem (1983) 26: 1551-1556 [PMID:6631913]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]