bovine adrenal medulla peptide 8-22 | Ligand Activity Charts

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bovine adrenal medulla peptide 8-22 (Human)
Ligand Activity Charts

bovine adrenal medulla peptide 8-22 [Ligand Id: 4058] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3343989
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2] Mas-related G-protein coupled receptor member X1 in Mouse [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3] Mas-related G-protein coupled receptor member X1 in Rat [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
GtoPdb	-	-	7.99	pKd	10.2	nM	Kd	Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
GtoPdb	-	-	7.68	pKi	21	nM	Ki	Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
ChEMBL	Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay	B	7.3	pEC50	50.12	nM	EC50	Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL	Agonist activity at human MrgprX1	B	7.3	pEC50	50	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
GtoPdb	-	-	7.8	pEC50	-	-	-	J Neurosci (2004) 24: 5044-53 [PMID:15163697]; Nat Neurosci (2002) 5: 201-9 [PMID:11850634]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
ChEMBL	Agonist activity at mouse MRGPRC11	B	6.52	pEC50	300	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
ChEMBL	Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay	B	6.6	pEC50	251.19	nM	EC50	Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
ChEMBL	Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay	B	6.5	pEC50	316.23	nM	EC50	Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL	Agonist activity at rat MRGPRC	B	6.52	pEC50	300	nM	EC50	J Med Chem (2019) 62: 8631-8641 [PMID:31498617]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]