bovine adrenal medulla peptide 8-22 [Ligand Id: 4058] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3343989
  • MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
  • Mas-related G-protein coupled receptor member X1 in Mouse [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
  • Mas-related G-protein coupled receptor member X1 in Rat [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
GtoPdb - - 7.99 pKd 10.2 nM Kd Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
GtoPdb - - 7.68 pKi 21 nM Ki Nat Neurosci (2002) 5: 201-9 [PMID:11850634]
ChEMBL Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay B 7.3 pEC50 50.12 nM EC50 Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL Agonist activity at human MrgprX1 B 7.3 pEC50 50 nM EC50 J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
GtoPdb - - 7.8 pEC50 - - - J Neurosci (2004) 24: 5044-53 [PMID:15163697];
Nat Neurosci (2002) 5: 201-9 [PMID:11850634];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
ChEMBL Agonist activity at mouse MRGPRC11 B 6.52 pEC50 300 nM EC50 J Med Chem (2019) 62: 8631-8641 [PMID:31498617]
ChEMBL Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay B 6.6 pEC50 251.19 nM EC50 Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
ChEMBL Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay B 6.5 pEC50 316.23 nM EC50 Bioorg Med Chem (2014) 22: 5831-5837 [PMID:25288495]
ChEMBL Agonist activity at rat MRGPRC B 6.52 pEC50 300 nM EC50 J Med Chem (2019) 62: 8631-8641 [PMID:31498617]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]