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ChEMBL ligand: CHEMBL3343989 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2] | ||||||||
GtoPdb | - | - | 7.99 | pKd | 10.2 | nM | Kd | Nat Neurosci (2002) 5: 201-9 [PMID:11850634] |
GtoPdb | - | - | 7.68 | pKi | 21 | nM | Ki | Nat Neurosci (2002) 5: 201-9 [PMID:11850634] |
ChEMBL | Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay | B | 7.3 | pEC50 | 50.12 | nM | EC50 | Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495] |
ChEMBL | Agonist activity at human MrgprX1 | B | 7.3 | pEC50 | 50 | nM | EC50 | J Med Chem (2019) 62: 8631-8641 [PMID:31498617] |
GtoPdb | - | - | 7.8 | pEC50 | - | - | - |
J Neurosci (2004) 24: 5044-53 [PMID:15163697]; Nat Neurosci (2002) 5: 201-9 [PMID:11850634]; J Biomol Screen (2013) 18: 599-609 [PMID:23396314] |
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3] | ||||||||
ChEMBL | Agonist activity at mouse MRGPRC11 | B | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2019) 62: 8631-8641 [PMID:31498617] |
ChEMBL | Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay | B | 6.6 | pEC50 | 251.19 | nM | EC50 | Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495] |
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1] | ||||||||
ChEMBL | Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay | B | 6.5 | pEC50 | 316.23 | nM | EC50 | Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495] |
ChEMBL | Agonist activity at rat MRGPRC | B | 6.52 | pEC50 | 300 | nM | EC50 | J Med Chem (2019) 62: 8631-8641 [PMID:31498617] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]