bovine adrenal medulla peptide 8-22 [Ligand Id: 4058] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3343989
  • MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
  • Mas-related G-protein coupled receptor member X1 in Mouse [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
  • Mas-related G-protein coupled receptor member X1 in Rat [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MRGPRX1/Mas-related G-protein coupled receptor member X1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5850] [GtoPdb: 156] [UniProtKB: Q96LB2]
GtoPdb - - 7.99 pKd 10.2 nM Kd Nat. Neurosci. (2002) 5: 201-9 [PMID:11850634]
GtoPdb - - 7.68 pKi 21 nM Ki Nat. Neurosci. (2002) 5: 201-9 [PMID:11850634]
ChEMBL Agonist activity at human MrgX1 transfected in HEK293 cells by FLIPR assay B 7.3 pEC50 50.12 nM EC50 Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]
GtoPdb - - 7.8 pEC50 - - - J. Neurosci. (2004) 24: 5044-53 [PMID:15163697];
Nat. Neurosci. (2002) 5: 201-9 [PMID:11850634];
J Biomol Screen (2013) 18: 599-609 [PMID:23396314]
Mas-related G-protein coupled receptor member X1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341576] [UniProtKB: Q8CIP3]
ChEMBL Agonist activity at mouse MrgC11 transfected in HEK293 cells by FLIPR assay B 6.6 pEC50 251.19 nM EC50 Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]
Mas-related G-protein coupled receptor member X1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3341575] [UniProtKB: Q8R4G1]
ChEMBL Agonist activity at rat MrgX1 transfected in HEK293 cells by FLIPR assay B 6.5 pEC50 316.23 nM EC50 Bioorg. Med. Chem. (2014) 22: 5831-5837 [PMID:25288495]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]