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ChEMBL ligand: CHEMBL488817 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
ChEMBL | Inhibition of human ERG | B | 5.42 | pIC50 | 3790 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
ChEMBL | Antagonist activity at human ERG by voltage-clamp electrophysiology assay | F | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
ChEMBL | Inhibition of sodium channel Nav1.5 by voltage-clamp method | B | 4.08 | pIC50 | 84000 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
ChEMBL | Inhibition of T-type calcium channel alpha1I by FLIPR | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60] | ||||||||
GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]