TTA-P2 [Ligand Id: 7723] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL488817 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Nav1.5/Sodium channel protein type 5 subunit alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of sodium channel Nav1.5 by voltage-clamp method | B | 4.08 | pIC50 | 84000 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
| Cav3.3/Voltage-dependent T-type calcium channel subunit alpha-1I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| ChEMBL | Inhibition of T-type calcium channel alpha1I by FLIPR | B | 7.09 | pIC50 | 82 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
| Kv11.1/Voltage-gated inwardly rectifying potassium channel KCNH2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibition of human ERG | B | 5.42 | pIC50 | 3790 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| ChEMBL | Antagonist activity at human ERG by voltage-clamp electrophysiology assay | F | 5.54 | pIC50 | 2900 | nM | IC50 | J Med Chem (2008) 51: 3692-3695 [PMID:18540666] |
| Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
| Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60] | ||||||||
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Mol Pharmacol (2011) 80: 900-10 [PMID:21821734] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
