TTA-P2 [Ligand Id: 7723] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL488817
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  • Nav1.5/Sodium channel protein type V alpha subunit in Human [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
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  • Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
  • Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
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  • Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
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  • Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibition of human ERG B 5.42 pIC50 3790 nM IC50 J Med Chem (2008) 51: 6471-6477 [PMID:18817368]
ChEMBL Antagonist activity at human ERG by voltage-clamp electrophysiology assay F 5.54 pIC50 2900 nM IC50 J Med Chem (2008) 51: 3692-3695 [PMID:18540666]
Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524]
ChEMBL Inhibition of sodium channel Nav1.5 by voltage-clamp method B 4.08 pIC50 84000 nM IC50 J Med Chem (2008) 51: 3692-3695 [PMID:18540666]
Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4]
ChEMBL Inhibition of T-type calcium channel alpha1I by FLIPR B 7.09 pIC50 82 nM IC50 J Med Chem (2008) 51: 6471-6477 [PMID:18817368]
Cav3.3 in Rat [GtoPdb: 537] [UniProtKB: Q9Z0Y8]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]
Cav3.1 in Rat [GtoPdb: 535] [UniProtKB: O54898]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]
Cav3.2 in Rat [GtoPdb: 536] [UniProtKB: Q9EQ60]
GtoPdb - - 7 pIC50 - - - Mol Pharmacol (2011) 80: 900-10 [PMID:21821734]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]