SC-41930 [Ligand Id: 6156] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL14823 (SC-41930)
  • BLT1 receptor/Leukotriene B4 receptor 1 in Human [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722]
ChEMBL In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay B 6.55 pKi 280 nM Ki Bioorg. Med. Chem. Lett. (1995) 5: 887-892
ChEMBL Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4 B 6.66 pKi 220 nM Ki J. Med. Chem. (1993) 36: 3333-3340 [PMID:8230123]
GtoPdb - - 7.77 pKi 17 nM Ki Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309]
GtoPdb - - 6.1 pIC50 808 nM IC50 Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309]
ChEMBL Binding affinity for Leukotriene B4 (LTB4) receptor B 6.49 pIC50 320 nM IC50 J. Med. Chem. (1995) 38: 858-868 [PMID:7699700]
ChEMBL Concentration inhibiting the binding of [3H]LTB4 to human neutrophils B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1992) 35: 4253-4255 [PMID:1331462]
ChEMBL Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs) B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1993) 36: 2703-2705 [PMID:8410983]
ChEMBL Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assay B 6.52 pIC50 300 nM IC50 J. Med. Chem. (1989) 32: 1145-1147 [PMID:2542550]
ChEMBL In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis F 6.85 pIC50 140 nM IC50 Bioorg. Med. Chem. Lett. (1995) 5: 887-892
ChEMBL Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA) B 7.37 pIC50 43 nM IC50 J. Med. Chem. (1995) 38: 858-868 [PMID:7699700]
ChEMBL Compound was tested for inhibitory activity against LTB4 (leukotriene) binding B 7.7 pIC50 20 nM IC50 J. Med. Chem. (1996) 39: 2629-2654 [PMID:8709092]
ChEMBL Inhibitory activity against leukotriene B4 receptor B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (1994) 4: 811-816

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]