SC-41930 [Ligand Id: 6156] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL14823 (SC-41930) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay | B | 6.55 | pKi | 280 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 887-892 |
| ChEMBL | Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4 | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (1993) 36: 3333-3340 [PMID:8230123] |
| GtoPdb | - | - | 7.77 | pKi | 17 | nM | Ki | Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309] |
| GtoPdb | - | - | 6.1 | pIC50 | 808 | nM | IC50 | Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309] |
| ChEMBL | Binding affinity for Leukotriene B4 (LTB4) receptor | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (1995) 38: 858-868 [PMID:7699700] |
| ChEMBL | Concentration inhibiting the binding of [3H]LTB4 to human neutrophils | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1992) 35: 4253-4255 [PMID:1331462] |
| ChEMBL | Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs) | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1993) 36: 2703-2705 [PMID:8410983] |
| ChEMBL | Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assay | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1989) 32: 1145-1147 [PMID:2542550] |
| ChEMBL | In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 887-892 |
| ChEMBL | Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA) | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1995) 38: 858-868 [PMID:7699700] |
| ChEMBL | Compound was tested for inhibitory activity against LTB4 (leukotriene) binding | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
| ChEMBL | Inhibitory activity against leukotriene B4 receptor | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 811-816 |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
