SC-41930 [Ligand Id: 6156] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL14823 (SC-41930) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| BLT1 receptor/Leukotriene B4 receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3911] [GtoPdb: 267] [UniProtKB: Q15722] | ||||||||
| ChEMBL | In vitro antagonist activity against leukotriene B4 (LTB4) receptor in [3H]-LTB4 human neutrophil receptor binding assay | B | 6.55 | pKi | 280 | nM | Ki | Bioorg Med Chem Lett (1995) 5: 887-892 |
| ChEMBL | Binding affinity against Leukotriene B4 receptor on intact differentiated U-937 cells in competitive binding assay with [3H]LTB4 | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (1993) 36: 3333-3340 [PMID:8230123] |
| GtoPdb | - | - | 7.77 | pKi | 17 | nM | Ki | Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309] |
| GtoPdb | - | - | 6.1 | pIC50 | 808 | nM | IC50 | Biochem Pharmacol (1995) 49: 1683-90 [PMID:7786309] |
| ChEMBL | Binding affinity for Leukotriene B4 (LTB4) receptor | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (1995) 38: 858-868 [PMID:7699700] |
| ChEMBL | Concentration inhibiting the binding of [3H]LTB4 to human neutrophils | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1992) 35: 4253-4255 [PMID:1331462] |
| ChEMBL | Inhibitory concentration against leukotriene receptor B4 (LTB4) in human polymorphonuclear cells (PMNs) | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1993) 36: 2703-2705 [PMID:8410983] |
| ChEMBL | Compound was evaluated in a human neutrophil leukotriene B4 receptor binding assay | B | 6.52 | pIC50 | 300 | nM | IC50 | J Med Chem (1989) 32: 1145-1147 [PMID:2542550] |
| ChEMBL | In vitro inhibitory activity against human neutrophil leukotriene B4 (LTB4) induced Chemotaxis | F | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (1995) 5: 887-892 |
| ChEMBL | Binding affinity towards Leukotriene B4 (LTB4) Receptor. (Experiment conducted in the absence of NDGA) | B | 7.37 | pIC50 | 43 | nM | IC50 | J Med Chem (1995) 38: 858-868 [PMID:7699700] |
| ChEMBL | Compound was tested for inhibitory activity against LTB4 (leukotriene) binding | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (1996) 39: 2629-2654 [PMID:8709092] |
| ChEMBL | Inhibitory activity against leukotriene B4 receptor | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 811-816 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
