ChEMBL ligand: CHEMBL255738
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519] There should be some charts here, you may need to enable JavaScript!
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase/Tyrosine-protein kinase ABL in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1862] [GtoPdb: 1923] [UniProtKB: P00519]
ChEMBL	Mixed-type inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.33	pKi	470	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.35	pKi	450	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL T315I mutant expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	6.4	pKi	400	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using abtide peptide as substrate	B	6.92	pKi	120	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant ABL expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	7	pKi	100	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of human recombinant Abl	B	7.36	pKi	44	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752]
GtoPdb	-	-	7.36	pKi	44	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-11 [PMID:18078752]; Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL267] [GtoPdb: 2206] [UniProtKB: P12931]
ChEMBL	Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using ATP as substrate	B	6.26	pKi	550	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of histidine-tagged human recombinant SRC expressed in baculovirus system assessed as [gamma32P]ATP utilization after 10 mins by liquid scintillation counting using KVEKIGEGTYGVVYK as substrate	B	6.26	pKi	550	nM	Ki	Bioorg Med Chem (2010) 18: 3999-4008 [PMID:20451394]
ChEMBL	Inhibition of recombinant human c-Src	B	6.45	pKi	354	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1207-1211 [PMID:18078752]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]