tezacaftor   Click here for help

GtoPdb Ligand ID: 10199

Synonyms: example 315 [US20090131492A1] | VX-661 | VX661
Approved drug PDB Ligand
tezacaftor is an approved drug (EMA & FDA (2018))
Compound class: Synthetic organic
Comment: Tezacaftor is a small molecule cystic fibrosis transmembrane conductance regulator (CFTR) modulator that was developed by Vertex Pharmaceuticals [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 4
Rotatable bonds 9
Topological polar surface area 113.18
Molecular weight 520.18
XLogP 2.67
No. Lipinski's rules broken 0
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Canonical SMILES OCC(Cn1c2cc(F)c(cc2cc1C(CO)(C)C)NC(=O)C1(CC1)c1ccc2c(c1)OC(O2)(F)F)O
Isomeric SMILES OC[C@@H](Cn1c2cc(F)c(cc2cc1C(CO)(C)C)NC(=O)C1(CC1)c1ccc2c(c1)OC(O2)(F)F)O
InChI InChI=1S/C26H27F3N2O6/c1-24(2,13-33)22-8-14-7-18(17(27)10-19(14)31(22)11-16(34)12-32)30-23(35)25(5-6-25)15-3-4-20-21(9-15)37-26(28,29)36-20/h3-4,7-10,16,32-34H,5-6,11-13H2,1-2H3,(H,30,35)/t16-/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2018))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10104 tezacaftor
Synonyms Click here for help
example 315 [US20090131492A1] | VX-661 | VX661
Database Links Click here for help
CAS Registry No. 1152311-62-0 (source: WHO INN record)
ChEMBL Ligand CHEMBL3544914
DrugCentral Ligand 5276
GtoPdb PubChem SID 381118909
PubChem CID 46199646
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UniChem Connectivity Search for chemical match using the InChIKey MJUVRTYWUMPBTR-MRXNPFEDSA-N