cilofexor   Click here for help

GtoPdb Ligand ID: 10644

Synonyms: example 13/9 [US10485795B2] | GS-9674 | GS9674
PDB Ligand
Compound class: Synthetic organic
Comment: Cilofexor (GS-9674) is a nonsteroidal farnesoid X receptor (FXR) agonist. It was originally identified by Phenex Pharmaceuticals [2] and is being developed by Gilead Pharmaceuticals for hepatic anti-steatotic activity, and potential to treat nonalcoholic fatty liver disease (NAFLD) and/or nonalcoholic steatohepatitis (NASH) [1,4]. Successful treatment of these liver conditions will most likely be achieved using combinations of antilipemic, anti-inflammatory and anti-fibrotic agents.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 108.92
Molecular weight 585.06
XLogP 6.49
No. Lipinski's rules broken 1
SMILES / InChI / InChIKey
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Canonical SMILES OC(=O)c1ccnc(c1)N1CC(C1)(O)c1ccc(cc1Cl)OCc1c(onc1c1c(Cl)cccc1Cl)C1CC1
Isomeric SMILES OC(=O)c1ccnc(c1)N1CC(C1)(O)c1ccc(cc1Cl)OCc1c(onc1c1c(Cl)cccc1Cl)C1CC1
InChI InChI=1S/C28H22Cl3N3O5/c29-20-2-1-3-21(30)24(20)25-18(26(39-33-25)15-4-5-15)12-38-17-6-7-19(22(31)11-17)28(37)13-34(14-28)23-10-16(27(35)36)8-9-32-23/h1-3,6-11,15,37H,4-5,12-14H2,(H,35,36)
InChI Key KZSKGLFYQAYZCO-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[3-[2-chloro-4-[[5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazol-4-yl]methoxy]phenyl]-3-hydroxyazetidin-1-yl]pyridine-4-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
10739 cilofexor
Synonyms Click here for help
example 13/9 [US10485795B2] | GS-9674 | GS9674
Database Links Click here for help
BindingDB Ligand 50511109
CAS Registry No. 1418274-28-8 (source: WHO INN record)
ChEMBL Ligand CHEMBL4297613
DrugBank Ligand DB15168
GtoPdb PubChem SID 404859091
PubChem CID 71228883
RCSB PDB Ligand 811
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UniChem Compound Search for chemical match using the InChIKey KZSKGLFYQAYZCO-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey KZSKGLFYQAYZCO-UHFFFAOYSA-N