abediterol [Ligand Id: 9326] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3039530 (Abediterol, LAS-100977, LAS100977) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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| β1-adrenoceptor/Beta-1 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL213] [GtoPdb: 28] [UniProtKB: P08588] | ||||||||
| GtoPdb | Membrane radioligand displacement assay using [3H]CGP12177 as tracer. | - | 7.44 | pIC50 | 36.2 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
| ChEMBL | Inhibition of 3H]CGP12177 binding to human beta1 adrenoceptor expressed in sf9 cell membranes incubated for 60 mins by scintillation counting method | B | 7.44 | pEC50 | 36.2 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| β2-adrenoceptor/Beta-2 adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL210] [GtoPdb: 29] [UniProtKB: P07550] | ||||||||
| GtoPdb | Membrane radioligand displacement assay using [3H]CGP12177 as tracer. | - | 9.22 | pIC50 | 0.6 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
| ChEMBL | Agonist activity at beta2 adrenoceptor human bronchi assessed as induction of maximum relaxation | F | 8.72 | pEC50 | 1.9 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| ChEMBL | Inhibition of 3H]CGP12177 binding to human beta2 adrenoceptor expressed in sf9 cell membranes incubated for 60 mins by scintillation counting method | B | 9.22 | pEC50 | 0.6 | nM | EC50 | J Med Chem (2020) 63: 15218-15242 [PMID:33213146] |
| β3-adrenoceptor in Human [GtoPdb: 30] [UniProtKB: P13945] | ||||||||
| GtoPdb | - | - | 5.52 | pIC50 | 3001 | nM | IC50 | J Pharmacol Exp Ther (2012) 342: 497-509 [PMID:22588259] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
