ChEMBL ligand: CHEMBL3355101
Aminopeptidase N in Human [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144] Aminopeptidase N in Pig [ChEMBL: CHEMBL2590] [UniProtKB: P15145] There should be some charts here, you may need to enable JavaScript!
Cytosol aminopeptidase in Pig [ChEMBL: CHEMBL5624] [UniProtKB: P28839] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 1 in Human [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08] There should be some charts here, you may need to enable JavaScript!
Endoplasmic reticulum aminopeptidase 2 in Human [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aminopeptidase N in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1907] [GtoPdb: 1560] [UniProtKB: P15144]
ChEMBL	Inhibition of human recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation	B	8.62	pKi	2.4	nM	Ki	J Med Chem (2014) 57: 8140-8151 [PMID:25192493]
Aminopeptidase N in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2590] [UniProtKB: P15145]
ChEMBL	Inhibition of pig recombinant alanyl aminopeptidase after 30 to 60 mins by morrison's equation	B	7.16	pKi	69	nM	Ki	J Med Chem (2014) 57: 8140-8151 [PMID:25192493]
Cytosol aminopeptidase in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5624] [UniProtKB: P28839]
ChEMBL	Inhibition of pig recombinant leucine aminopeptidase after 30 to 60 mins by morrison's equation	B	6.67	pKi	215	nM	Ki	J Med Chem (2014) 57: 8140-8151 [PMID:25192493]
Endoplasmic reticulum aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5939] [GtoPdb: 1566] [UniProtKB: Q9NZ08]
ChEMBL	Inhibition of human ERAP1 preincubated for 30 to 60 mins followed by addition of Leu-AMC as substrate measured for 15 mins by spectrofluorimetric method	B	6.28	pKi	530	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4122-4126 [PMID:27390066]
GtoPdb	-	-	6.28	pKi	530	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066]
Endoplasmic reticulum aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5043] [GtoPdb: 1567] [UniProtKB: Q6P179]
ChEMBL	Inhibition of human ERAP2 preincubated for 30 to 60 mins followed by addition of Arg-AMC as substrate measured for 15 mins by spectrofluorimetric method	B	6.82	pKi	152	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4122-4126 [PMID:27390066]
GtoPdb	-	-	6.82	pKi	150	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4122-6 [PMID:27390066]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]