acesulfame [Ligand Id: 12460] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL176687 (Acesulfame)
  • carbonic anhydrase 2/Carbonic anhydrase II in Human [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
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  • carbonic anhydrase 9/Carbonic anhydrase IX in Human [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
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  • TAS2R31 in Human [GtoPdb: 674] [UniProtKB: P59538]
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  • TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918]
ChEMBL Binding affinity to carbonic anhydrase 2 (unknown origin) B 4.7 pKi >20000 nM Ki ACS Med Chem Lett (2018) 9: 657-661 [PMID:30034596]
carbonic anhydrase 9/Carbonic anhydrase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3594] [GtoPdb: 3055] [UniProtKB: Q16790]
ChEMBL Binding affinity to carbonic anhydrase 9 (unknown origin) expressed in Escherichia coli BL21 (DE3) B 5.62 pKi 2400 nM Ki ACS Med Chem Lett (2018) 9: 657-661 [PMID:30034596]
TAS2R31 in Human [GtoPdb: 674] [UniProtKB: P59538]
GtoPdb - - 2.6 pEC50 2500000 nM EC50 J Neurosci (2004) 24: 10260-5 [PMID:15537898]
TAS2R43 in Human [GtoPdb: 678] [UniProtKB: P59537]
GtoPdb - - 2.51 pEC50 3100000 nM EC50 J Neurosci (2004) 24: 10260-5 [PMID:15537898]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]