ChEMBL ligand: CHEMBL435582
GluA1/Glutamate receptor ionotropic, AMPA 1 in Human [ChEMBL: CHEMBL2009] [GtoPdb: 444] [UniProtKB: P42261] There should be some charts here, you may need to enable JavaScript!
GluA2/Glutamate receptor ionotropic, AMPA 2 in Human [ChEMBL: CHEMBL4016] [GtoPdb: 445] [UniProtKB: P42262] There should be some charts here, you may need to enable JavaScript!
GluA3/Glutamate receptor ionotropic, AMPA 3 in Human [ChEMBL: CHEMBL3595] [GtoPdb: 446] [UniProtKB: P42263] There should be some charts here, you may need to enable JavaScript!
GluA4/Glutamate receptor ionotropic, AMPA 4 in Human [ChEMBL: CHEMBL3190] [GtoPdb: 447] [UniProtKB: P48058] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
GluA1/Glutamate receptor ionotropic, AMPA 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2009] [GtoPdb: 444] [UniProtKB: P42261]
ChEMBL	Inhibition of GluR1 expressed in HEK cells	B	5.25	pEC50	5650	nM	EC50	J Med Chem (2010) 53: 7271-7279 [PMID:20839777]
GtoPdb	-	-	5.25	pEC50	5650	nM	EC50	Neuropharmacology (2001) 40: 976-83 [PMID:11406188]
GluA2/Glutamate receptor ionotropic, AMPA 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4016] [GtoPdb: 445] [UniProtKB: P42262]
ChEMBL	Activity against human GLUR2 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assay	F	5.72	pEC50	1905	nM	EC50	Bioorg Med Chem Lett (2006) 16: 5057-5061 [PMID:16879964]
ChEMBL	Inhibition of GluR2 flop expressed in HEK cells	B	5.84	pEC50	1440	nM	EC50	J Med Chem (2010) 53: 7271-7279 [PMID:20839777]
ChEMBL	Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assay	F	6.25	pEC50	559	nM	EC50	Bioorg Med Chem Lett (2006) 16: 5057-5061 [PMID:16879964]
GtoPdb	-	-	6.82	pEC50	150	nM	EC50	Neuropharmacology (2001) 40: 976-83 [PMID:11406188]
ChEMBL	Agonist activity at GluR2 receptor	F	6.82	pEC50	150	nM	EC50	J Med Chem (2010) 53: 7271-7279 [PMID:20839777]
GluA3/Glutamate receptor ionotropic, AMPA 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3595] [GtoPdb: 446] [UniProtKB: P42263]
ChEMBL	Inhibition of GluR3 expressed in HEK cells	B	5.78	pEC50	1660	nM	EC50	J Med Chem (2010) 53: 7271-7279 [PMID:20839777]
GtoPdb	-	-	5.78	pEC50	1660	nM	EC50	Neuropharmacology (2001) 40: 976-83 [PMID:11406188]
GluA4/Glutamate receptor ionotropic, AMPA 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3190] [GtoPdb: 447] [UniProtKB: P48058]
ChEMBL	Activity against human GLUR4 flop expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assay	F	5.97	pEC50	1061	nM	EC50	Bioorg Med Chem Lett (2006) 16: 5057-5061 [PMID:16879964]
ChEMBL	Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamate-stimulated calcium influx by FLIPR assay	F	6.38	pEC50	420	nM	EC50	Bioorg Med Chem Lett (2006) 16: 5057-5061 [PMID:16879964]
ChEMBL	Tested for potentiation towards human iGluR4 receptor expressed in HEK293 cells	F	6.54	pEC50	290	nM	EC50	J Med Chem (2000) 43: 4354-4358 [PMID:11087558]
ChEMBL	Potentiation of responses mediated by 100 uM L-glutamate in transfected HEK293 cells expressing human homomeric iGluR4 flip receptors.	F	6.54	pEC50	290	nM	EC50	J Med Chem (2002) 45: 2101-2111 [PMID:11985477]
ChEMBL	Inhibition of GluR4 expressed in HEK293 cells	B	6.54	pEC50	290	nM	EC50	J Med Chem (2010) 53: 7271-7279 [PMID:20839777]
GtoPdb	-	-	6.68	pEC50	210	nM	EC50	Neuropharmacology (2001) 40: 976-83 [PMID:11406188]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]