hydralazine [Ligand Id: 7326] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL276832 (Hydralazine, Hydralazine polistirex, NSC-126699)
  • Aldehyde oxidase in Human [ChEMBL: CHEMBL3257] [UniProtKB: Q06278]
  • This target only has 0 pki data point
  • 0
1 CHEMBL276832_lig_chart_1 Aldehyde oxidase Human
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  • Arachidonate 15-lipoxygenase in Rabbit [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
  • This target only has 0 pki data point
  • 0
2 CHEMBL276832_lig_chart_2 Arachidonate 15-lipoxygenase Rabbit
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  • Lactoperoxidase in Bovine [ChEMBL: CHEMBL2295561] [UniProtKB: P80025]
  • This target only has 0 pki data point
  • 0
3 CHEMBL276832_lig_chart_3 Lactoperoxidase Bovine
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  • myeloperoxidase/Myeloperoxidase in Human [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
  • This target only has 0 pki data point
  • 0
4 CHEMBL276832_lig_chart_4 Myeloperoxidase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aldehyde oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3257] [UniProtKB: Q06278]
ChEMBL Inhibition of aldehyde oxidase in human liver cytosolic fraction using methyl-nicotinamide substrate incubated for 120 mins by HPLC analysis B 5.41 pIC50 3930 nM IC50 WO-2018198842-A1. Therapeutic agent for nonalcoholic fatty liver disease (null)
Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530]
ChEMBL DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) B 5.44 pIC50 3649 nM IC50 DrugMatrix in vitro pharmacology data
Lactoperoxidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2295561] [UniProtKB: P80025]
ChEMBL Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins B 5.92 pIC50 1200 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164]
ChEMBL Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA B 5.63 pIC50 2360 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]
ChEMBL Irreversible inhibition of MPO (unknown origin) B 6.05 pIC50 900 nM IC50 ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313]
ChEMBL Inhibition of human MPO B 6.05 pIC50 900 nM IC50 ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313]
ChEMBL Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins B 6.05 pIC50 900 nM IC50 J Med Chem (2017) 60: 6563-6586 [PMID:28671460]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]