hydralazine [Ligand Id: 7326] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL276832 (Hidralazina, Hydralazine, Hydralazine polistirex, NSC-126699) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldehyde oxidase 1/Aldehyde oxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3257] [GtoPdb: 3186] [UniProtKB: Q06278] | ||||||||
| ChEMBL | Inhibition of aldehyde oxidase in human liver cytosolic fraction using methyl-nicotinamide substrate incubated for 120 mins by HPLC analysis | B | 5.41 | pIC50 | 3930 | nM | IC50 | WO-2018198842-A1. Therapeutic agent for nonalcoholic fatty liver disease (2018) |
| Arachidonate 15-lipoxygenase in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4358] [UniProtKB: P12530] | ||||||||
| ChEMBL | DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) | B | 5.44 | pIC50 | 3649 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Aspartate aminotransferase, cytoplasmic in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2189139] [UniProtKB: P17174] | ||||||||
| ChEMBL | Inhibition of GOT1 (unknown origin) using aspartic acid and alpha-ketoglutaric acid as substrates assessed as reduction in absorbance of NADH incubated for 20 mins in presence of MDH1 and NADH by HTS assay | B | 4.57 | pIC50 | 26620 | nM | IC50 | Bioorg Med Chem Lett (2022) 73: 128883-128883 [PMID:35820623] |
| Lactoperoxidase in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2295561] [UniProtKB: P80025] | ||||||||
| ChEMBL | Inhibition of bovine milk LPO assessed as reduction in NaOSCN production in presence of H2O2/NaSCN after 5 mins | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
| myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
| ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA | B | 5.63 | pIC50 | 2360 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
| ChEMBL | Irreversible inhibition of MPO (unknown origin) | B | 6.05 | pIC50 | 900 | nM | IC50 | ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313] |
| ChEMBL | Inhibition of human MPO | B | 6.05 | pIC50 | 900 | nM | IC50 | ACS Med Chem Lett (2017) 8: 206-210 [PMID:28197313] |
| ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins | B | 6.05 | pIC50 | 900 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
| Peroxisomal acyl-coenzyme A oxidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105748] [UniProtKB: Q15067] | ||||||||
| ChEMBL | Inhibition of human recombinant AOX in presence of NAD+ and NADPH | B | 6.38 | pIC50 | 420 | nM | IC50 | ACS Med Chem Lett (2023) 14: 614-620 [PMID:37197460] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
