1.2.3.1 Aldehyde oxidase

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1.2.3.1 Aldehyde oxidase

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Enzymes

3186

aldehyde oxidase 1 Show summary »« Hide summary

Target Id	3186
Nomenclature	aldehyde oxidase 1
Genes	AOX1 (Hs), Aox1 (Mm), Aox1 (Rn)
Ensembl ID	ENSG00000138356 (Hs), ENSMUSG00000063558 (Mm), ENSRNOG00000015354 (Rn)
UniProtKB AC	Q06278 (Hs), O54754 (Mm)
Comment	Aldehyde oxidase 1 is a cytosolic enzyme that catalyses the oxidation of aldehydes into carboxylic acid and hydrogen peroxide. It is an important hepatic drug-metabolising enzyme [2-3], and its involvement in free-radical generation has implicated its activity in disease pathology [1,4].

References

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1. Berger R, Mezey E, Clancy KP, Harta G, Wright RM, Repine JE, Brown RH, Brownstein M, Patterson D. (1995) Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis. Somat Cell Mol Genet, 21 (2): 121-31. [PMID:7570184]

2. Garattini E, Terao M. (2012) The role of aldehyde oxidase in drug metabolism. Expert Opin Drug Metab Toxicol, 8 (4): 487-503. [PMID:22335465]

3. Sodhi JK, Wong S, Kirkpatrick DS, Liu L, Khojasteh SC, Hop CE, Barr JT, Jones JP, Halladay JS. (2015) A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834. Drug Metab Dispos, 43 (6): 908-15. [PMID:25845827]

4. Wright RM, Repine JE. (1997) The human molybdenum hydroxylase gene family: co-conspirators in metabolic free-radical generation and disease. Biochem Soc Trans, 25 (3): 799-804. [PMID:9388549]

How to cite this family page

Database page citation:

1.2.3.1 Aldehyde oxidase. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=1068.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.