Synonyms: Bisolvon® | NA-274 | NA274
bromhexine is an approved drug
Compound class:
Synthetic organic
Comment: Bromhexine is a widely used mucolytic (expectorant) drug. In response to the SARS-CoV-2 pandemic of 2019/20 it was investigated as an add-on treatment for patients with COVID-19 [1]. In addition to its mucolytic activity, bromhexine may also inhibit the human protease TMPRSS2 that is exploited by certain coronaviruses for spike (S) protein priming, thus reducing the viruses' infection mechanism [2].
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes |
Approved drug? | Yes. |
Is prodrug? | Yes |
Active form | ambroxol |
IUPAC Name ![]() |
2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl]aniline |
International Nonproprietary Names ![]() |
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INN number | INN |
2584 | bromhexine |
Synonyms ![]() |
Bisolvon® | NA-274 | NA274 |
Database Links ![]() |
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CAS Registry No. | 3572-43-8 (source: ChemIDplus) |
ChEMBL Ligand | CHEMBL253376 |
DrugBank Ligand | DB09019 |
DrugCentral Ligand | 402 |
GtoPdb PubChem SID | 434122278 |
PubChem CID | 2442 |
Search Google for chemical match using the InChIKey | OJGDCBLYJGHCIH-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | OJGDCBLYJGHCIH |
Search PubMed clinical trials | bromhexine |
Search PubMed titles | bromhexine |
Search PubMed titles/abstracts | bromhexine |
UniChem Compound Search for chemical match using the InChIKey | OJGDCBLYJGHCIH-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OJGDCBLYJGHCIH-UHFFFAOYSA-N |