ChEMBL ligand: CHEMBL145085 (Alpha-V Beta-3 Antagonist)
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) in Human [ChEMBL: CHEMBL2111425] [GtoPdb: 2457, 2455, 2453, 2444] [UniProtKB: P05106, P05556, P06756, P08648] There should be some charts here, you may need to enable JavaScript!
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Integrin alpha-5/beta-1 in Human [ChEMBL: CHEMBL2095226] [GtoPdb: 2455, 2444] [UniProtKB: P05556, P08648] There should be some charts here, you may need to enable JavaScript!
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514] There should be some charts here, you may need to enable JavaScript!
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha V subunit/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2111425] [GtoPdb: 2457, 2455, 2453, 2444] [UniProtKB: P05106, P05556, P06756, P08648]
ChEMBL	Antagonist activity at integrin alphavbeta3alpha5beta1 in human A375M cells assessed as inhibition of cell adhesion to fibronectin in presence of Mg2+	F	6.09	pIC50	810	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4117-4121 [PMID:22572578]
GtoPdb	Binding to the αvβ3 integrin using a scintillation-proximity assay (SPAV3).	-	7.1	pIC50	80	nM	IC50	J Med Chem (2003) 46: 4790-8 [PMID:14561098]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Integrin alpha-5/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095226] [GtoPdb: 2455, 2444] [UniProtKB: P05556, P08648]
ChEMBL	Antagonist activity at integrin alpha5beta1 in human K562 cells assessed as inhibition of cell adhesion	F	5.34	pIC50	4600	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4117-4121 [PMID:22572578]
ChEMBL	Antagonist activity at integrin alpha5beta1 in human A375M cells assessed as inhibition of cell adhesion in presence of Mg2+ and MK-0429	F	5.66	pIC50	2200	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4117-4121 [PMID:22572578]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 2457, 2441] [UniProtKB: P05106, P08514]
ChEMBL	Inhibition of alphaIIb-beta3 integrin mediated platelet aggregation	B	4.46	pIC50	34700	nM	IC50	J Med Chem (2003) 46: 4790-4798 [PMID:14561098]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha V subunit/Integrin alpha-V/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907598] [GtoPdb: 2457, 2453] [UniProtKB: P05106, P06756]
GtoPdb	Binding to the αvβ3 integrin using a scintillation-proximity assay (SPAV3).	-	7.1	pIC50	80	nM	IC50	J Med Chem (2003) 46: 4790-8 [PMID:14561098]
ChEMBL	Inhibition of human integrin alphavbeta3 expressed in HEK293 cells assessed as reduction in cell adhesion to fibrinogen preincubated for 20 mins followed by phosphatase substrate addition and measured after 1 hr by spectrophotometry	B	8.52	pIC50	3	nM	IC50	J Med Chem (2020) 63: 5675-5696 [PMID:31999923]
ChEMBL	Antagonist activity at integrin alphaVbeta3 in human A375M cells assessed as cell adhesion to fibrinogen in presence of Mg2+	F	9.52	pIC50	0.3	nM	IC50	Bioorg Med Chem Lett (2012) 22: 4117-4121 [PMID:22572578]
ChEMBL	Inhibition of alphaV-beta3 integrin binding	B	10.1	pIC50	0.08	nM	IC50	J Med Chem (2003) 46: 4790-4798 [PMID:14561098]
ChEMBL	Inhibition of integrin alphaVbeta3	B	10.1	pIC50	0.08	nM	IC50	J Med Chem (2010) 53: 4332-4353 [PMID:20218623]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]