bindarit [Ligand Id: 11124] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2107549 (AF 2838, AF-2838, Bindarit)
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  • fatty acid binding protein 4 in Human [GtoPdb: 2534] [UniProtKB: P15090]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427]
ChEMBL Binding affinity to human MCT4 expressed in Xenopus laevis oocytes assessed as inhibition constant in presence of [14C]lactate by fluorescence assay B 4.52 pKi 30200 nM Ki Eur J Med Chem (2020) 199: 112393-112393 [PMID:32388280]
fatty acid binding protein 4 in Human [GtoPdb: 2534] [UniProtKB: P15090]
GtoPdb Measuring displacement of [3H]-oleic acid from hFABP4 in a competitive binding assay. - 4.72 pKi 19000 nM Ki Sci Rep (2019) 9: 15155 [PMID:31641194]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]