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ChEMBL ligand: CHEMBL2107549 (AF 2838, AF-2838, Bindarit) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Monocarboxylate transporter 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073663] [GtoPdb: 989] [UniProtKB: O15427] | ||||||||
ChEMBL | Binding affinity to human MCT4 expressed in Xenopus laevis oocytes assessed as inhibition constant in presence of [14C]lactate by fluorescence assay | B | 4.52 | pKi | 30200 | nM | Ki | Eur J Med Chem (2020) 199: 112393-112393 [PMID:32388280] |
fatty acid binding protein 4 in Human [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
GtoPdb | Measuring displacement of [3H]-oleic acid from hFABP4 in a competitive binding assay. | - | 4.72 | pKi | 19000 | nM | Ki | Sci Rep (2019) 9: 15155 [PMID:31641194] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]