fatty acid binding protein 4 | Fatty acid-binding proteins | IUPHAR/BPS Guide to PHARMACOLOGY

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fatty acid binding protein 4

Target not currently curated in GtoImmuPdb

Target id: 2534

Nomenclature: fatty acid binding protein 4

Family: Fatty acid-binding proteins

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 132 8q21.13 FABP4 fatty acid binding protein 4
Mouse - 132 3 A1 Fabp4 fatty acid binding protein 4, adipocyte
Rat - 132 2q23 Fabp4 fatty acid binding protein 4
Previous and Unofficial Names
adipocyte lipid-binding protein | adipocyte protein aP2 | AFABP | ALBP
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of mouse adipocyte fatty acid binding ptortin bound by inhibitor.
PDB Id:  3HK1
Ligand:  HTS01037
Resolution:  1.7Å
Species:  Mouse
References:  1
Rank order of potency (Human)
oleic acid, palmitic acid, stearic acid, linoleic acid > α-linolenic acid, arachidonic acid  [3]

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
HM50316 Hs Inhibition >9.0 pKi 2
pKi >9.0 (Ki <1x10-9 M) [2]
compound 13 [PMID: 17502136] Hs Inhibition 8.7 pKi 4
pKi 8.7 (Ki 2x10-9 M) [4]
HTS01037 Mm Inhibition 6.2 pKi 1
pKi 6.2 (Ki 6.7x10-7 M) [1]
View species-specific inhibitor tables


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1. Hertzel AV, Hellberg K, Reynolds JM, Kruse AC, Juhlmann BE, Smith AJ, Sanders MA, Ohlendorf DH, Suttles J, Bernlohr DA. (2009) Identification and characterization of a small molecule inhibitor of Fatty Acid binding proteins. J. Med. Chem., 52 (19): 6024-31. [PMID:19754198]

2. Liu X, Huang X, Lin W, Wang D, Diao Y, Li H, Hui X, Wang Y, Xu A, Wu D et al.. (2011) New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein. Bioorg. Med. Chem. Lett., 21 (10): 2949-52. [PMID:21481589]

3. Richieri GV, Ogata RT, Kleinfeld AM. (1994) Equilibrium constants for the binding of fatty acids with fatty acid-binding proteins from adipocyte, intestine, heart, and liver measured with the fluorescent probe ADIFAB. J. Biol. Chem., 269 (39): 23918-30. [PMID:7929039]

4. Sulsky R, Magnin DR, Huang Y, Simpkins L, Taunk P, Patel M, Zhu Y, Stouch TR, Bassolino-Klimas D, Parker R et al.. (2007) Potent and selective biphenyl azole inhibitors of adipocyte fatty acid binding protein (aFABP). Bioorg. Med. Chem. Lett., 17 (12): 3511-5. [PMID:17502136]

How to cite this page

Fatty acid-binding proteins: fatty acid binding protein 4. Last modified on 12/07/2018. Accessed on 16/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2534.