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Targets Associated with Immuno Processes - Cytokine production & signalling

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Cytokine production & signalling Download as CSV

Targets Associated to Immuno Processes

  • GtoPdb receptor name: Linked to detailed view page for target. The target family is shown in brackets.
  • Process Association Comments: Comments provided by GtoImmuPdb curators giving more information about why the target is associated with Cytokine production & signalling.
  • GO Associations: Specific, immuno-relevant Gene Ontology terms annotated against the target. These show the term, its ID and GO evidence code. GO annotations with GO 'IEA' evidence are italicized to to indicate that these are annotations applied by GO without curatorial judgement, so should be used with caution.
  • Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.

Full documentation can be found in the GtoImmuPdb immuno cell type data documentation (PDF).

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Other Protein Targets
GtoPdb receptor name (family) Process Association Comments GO Associations Immunopharmacology Comments
regulator of G-protein signaling 10
(R12 family)		 T cells, macrophages, osteoclasts and microglia.
Expression of RGS10 in microglia suppresses pro-inflammatory signalling. RGS10 expression is silenced following microglial activation (by IFNγ for example) and this amplifies inflammatory responses in the central nervous system. Small molecules that can reverse IFNγ-mediated RGS10 silencing have been reported [7] ...